Results 11 to 20 of about 1,103,793 (328)

Phenotypic Characterization of Multidrug-resistant Escherichia Coli with Special Reference to Extended-spectrum-beta-lactamases and Metallo-beta-lactamases in a Tertiary Care Center

Journal of Nepal Medical Association, 2015
Introduction: The increasing reports on extended-spectrum-beta-lactamase and metallo-betalactamase producing Escherichia coli have addressed a potential threat to global health since it is found to be highly resistance to most of the currently available ...
Basudha Shrestha, Shovita Shrestha, Shyam Kumar Mishra, Hari Prasad Kattel, Tatsuya Tada, Hiroshi Ohara, Teruo Kirikae, Basista Prasad Rijal, Jeevan Bahadur Sherchand, Bharat Mani Pokhrel   +9 more
doaj   +3 more sources

Impact of short-term storage on the quantity of extended-spectrum beta-lactamase–producing Escherichia coli in broiler litter under practical conditions [PDF]

, 2020
Applying broiler litter containing extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli (E. coli) to arable land poses a potential risk for humans to get colonized by contact with contaminated soil or vegetables.
Daehre, Katrin, Nübel, Ulrich, Roesler, Uwe, Siller, Paul, Thiel, Nadine   +4 more
core   +1 more source

Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam.
Ruslan Tsivkovski, M. Totrov, O. Lomovskaya   +2 more
semanticscholar   +1 more source

MALDI-TOF MS Indirect Beta-Lactamase Detection in Ampicillin-Resistant Haemophilus influenzae

Microorganisms, 2023
Rapid identification of beta-lactamase-producing strains of Haemophilus influenzae plays key role in diagnostics in clinical microbiology. Therefore, the aim of this study was the rapid determination of beta-lactamase’s presence in H. influenzae isolates
Lukas Hleba, Miroslava Hlebova, Eva Kovacikova, Anton Kovacik   +3 more
doaj   +1 more source

In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an investigational ultrabroad-spectrum-beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in isogenic strains of Gram ...
Kirk J. Nelson, Debora Rubio-Aparicio, Dongxu Sun, M. Dudley, O. Lomovskaya   +4 more
semanticscholar   +1 more source

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays.
O. Lomovskaya, Ruslan Tsivkovski, Kirk J. Nelson, Debora Rubio-Aparicio, Dongxu Sun, M. Totrov, M. Dudley   +6 more
semanticscholar   +1 more source

Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]

, 2016
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
core   +2 more sources

Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes.
O. Lomovskaya, Kirk J. Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, M. Dudley   +5 more
semanticscholar   +1 more source

Presence of different beta-lactamase classes among clinical isolates of Pseudomonas aeruginosa expressing AmpC beta-lactamase enzyme

Journal of Infection in Developing Countries, 2010
Introduction: Infections caused by Pseudomonas aeruginosa are difficult to treat as the majority of isolates exhibit varying degrees of beta-lactamase mediated resistance to most of the beta-lactam antibiotics.
Supriya Upadhyay, Malay Ranjan Sen, Amitabha Bhattacharjee   +2 more
doaj   +1 more source

Combined effects of antibiotics and acidified nitrite on biofilm formation by beta-lactamase-producing uropathogenic bacteria

Zanco Journal of Medical Sciences, 2023
Background and objective: The increased prevalence of extended- spectrum beta-lactamase producing Enterobacteriaceae has increased the use of last-resort antimicrobial drugs like Carbapenems.
Hozan Yousif Hassan, Safaa Toma Hanna Aka, Aras Najmaddin Hamad, Salah Tofik Jalal Balaky   +3 more
doaj   +1 more source