Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore. The spectrum of beta-lactamase inhibition by vaborbactam and the impact of bacterial efflux and permeability on its activity were determined ...
semanticscholar +1 more source
The Distribution of ESBL-Producing Enterobacteriaceae: Leicestershire UK Compared to Worldwide [PDF]
open access ...
Reid, R. +2 more
core +1 more source
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
A +173 more
core +4 more sources
Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria
Background: Beta-lactamase genes are one of the most important groups of antimicrobial resistance genes in human and animal health. Therefore, continuous surveillance of this group of resistance genes is needed for a better understanding of the local ...
Babafela B. Awosile +4 more
doaj +1 more source
Carriage of plasmidic ampc beta-lactamase producing escherichia coli in cattle and sheep and characterisation of the isolates in terms of antibiogram profiles, phylogeny and virulence [PDF]
AmpC type beta-lactamase enzyme production by Escherichia coli confers resistance to penicillin and cephalosporins including oxyiminocephalosporin, cephamycin and aztreonam (variably).
Faruk PEHLIVANOGLU +2 more
doaj +1 more source
Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick +7 more
core +1 more source
Background: AmpC beta-lactamase-producing bacteria are associated with increased resistance to third-generation cephalosporins. Here, we describe plasmid-mediated AmpC beta-lactamase-producing enterobacteria isolated from urban and rural dwellers in ...
Christine F Najjuka +9 more
doaj +1 more source
Antibiotic use in Australian and Swedish primary care: a cross-country comparison
Objective Antimicrobial resistance is a growing worldwide problem and is considered to be one of the biggest threats to global health by the World Health Organization.
Konny Andersson +4 more
doaj +1 more source
Background: The incidence of antibiotic resistance in commensal bacteria is increasing with the production of extended-spectrum beta-lactamase. Therefore, this study was conducted to understand the status of fecal carriage of such enzyme producing ...
Birat Sharma +8 more
doaj +1 more source
Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru [PDF]
Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have ...
A. Appelgren +9 more
core +3 more sources

