Results 31 to 40 of about 52,329 (268)

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

First Detection of Carbapenem-Resistant Escherichia fergusonii Strains Harbouring Beta-Lactamase Genes from Clinical Samples

Pathogens, 2019
Recently discovered extraintestinal Escherichia fergusonii obtained from non-clinical samples has exhibited the potential for acquiring multiple beta-lactamase genes, just like many extraintestinal Escherichia coli strains. Albeit, they are often omitted
Tomilola Adesina, Obinna Nwinyi, Nandita De, Olayemi Akinnola, Emmanuel Omonigbehin   +4 more
doaj   +1 more source

Detection of genes mediating beta-lactamase production in isolates of enterobacteria recovered from wild pets in Saudi Arabia [PDF]

Veterinary World, 2015
Aim: To determine the genetic basis and types of beta-lactamase encountered among enterobacterial isolates of wild pets from the animal exhibit. Materials and Methods: A total of 17 beta-lactamase-producing enterobacteria recovered from fecal samples of
Sabry A. Hassan , Mohamed Y. Shobrak
doaj   +1 more source

High burden of ESBL and carbapenemase-producing gram-negative bacteria in bloodstream infection patients at a tertiary care hospital in Addis Ababa, Ethiopia

PLoS ONE, 2023
Background Bloodstream infection due to beta-lactamase and carbapenemase-producing gram-negative bacteria poses a substantial challenge to the effectiveness of antimicrobial treatments.
Daniel Beshah, Adey Feleke Desta, Gurja Belay Woldemichael, Esmael Besufikad Belachew, Solomon Gizaw Derese, Tizazu Zenebe Zelelie, Zelalem Desalegn, Tesfaye Sisay Tessema, Solomon Gebreselasie, Tamrat Abebe   +9 more
doaj  

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Antimicrobial Resistance and Infection Control, 2017
Background Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment.
Fithamlak Bisetegen Solomon, Fiseha Wadilo, Efrata Girma Tufa, Meseret Mitiku   +3 more
doaj   +1 more source

Antibacterial potential of neem (Azadirachta indica) against uropathogens producing beta-lactamase enzymes: A clue to future antibacterial agent?

Biomedical and Biotechnology Research Journal, 2020
Background: Emergence of drug resistance in Gram-negative bacilli due to production of extended-spectrum beta-lactamases (ESBL), metallo-beta-lactamases (MBL), and AmpC beta-lactamase is very common nowadays; therefore, we are left with less choice for ...
Sameer Singh Faujdar, Dakshina Bisht, Amisha Sharma   +2 more
doaj   +1 more source

Application of Raman spectroscopy in the hospital environment

Translational Biophotonics, Volume 4, Issue 4, December 2022., 2022
The hospital environment has unique microbiological characteristics that require extensive management to avoid contamination of both humans and the natural environment. Label‐free Raman spectroscopy is an effective tool for this purpose with various applications ranging from infectious disease diagnostics over infection control to food and water safety.
Aikaterini Pistiki, Markus Salbreiter, Salwa Sultan, Petra Rösch, Jürgen Popp   +4 more
wiley   +1 more source

Detection of beta lactamase in sputum. [PDF]

Journal of Clinical Pathology, 1994
To develop a rapid, sensitive, and reproducible test for the detection of beta lactamase in sputum, and to relate these findings to bacteriological culture results.One hundred and twenty sputum samples from inpatients were investigated for beta lactamase activity using the chromogenic cephalosporin nitrocefin.
J. Corkill, S. Aspinall, C. Connell
openaire   +3 more sources

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

Advanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo, Qi Wang, Xiaotong Fan, Xue Qi Koh, Xian Jun Loh, Caisheng Wu, Zibiao Li, Yun‐Long Wu   +7 more
wiley   +1 more source

Extended‐Spectrum Beta‐Lactamases [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 2006
The definition of extended‐spectrum beta‐lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world. In Canada, the problem has grown less rapidly than in other parts of the world; however, ESBLs still present a significant impediment to the
openaire   +3 more sources