Results 71 to 80 of about 1,103,793 (328)

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

GC-MS profiling, Beta-lactamase Inhibition Assay, and Molecular Docking Studies on Selected Medicinal Plants

UMYU Journal of Microbiology Research
Bacterial infections are continually developing resistance to conventional antibiotic agents, thereby prompting the search for bioactive compounds from plant parts that would serve as lead molecules in the discovery and development of new drugs.
Ubamaka W Ike, Osinachi Samdavid Okpara, Chidi Ijeoma Nosiri, G Enyinnaya Eze, Chinedu Aguwamba, Chinomso Friday Aaron, Okamgba, C. O., S C Okereke   +7 more
doaj   +1 more source

Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Journal of Biomedical Science, 2019
Background This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhibitors enhancing the activity of ...
Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata, Ebthag M. Awad   +3 more
doaj   +1 more source

Detection of New Delhi metallo-beta-lactamase and extended-spectrum beta-lactamase genes in Escherichia coli isolated from mastitic milk samples.

Transboundary and Emerging Diseases, 2013
In this study, eight Escherichia coli isolates were obtained from milk samples of dairy cattle suffering from clinical/subclinical mastitis. Isolates were characterized for antimicrobial resistance traits and virulence genes.
S. Ghatak, A. Singha, Abhik Sen, C. Guha, A. Ahuja, U. Bhattacharjee, Samir Das, N. Pradhan, K. Puro, C. Jana, T. K. Dey, K. L. Prashantkumar, A. Das, I. Shakuntala, U. Biswas, P. Jana   +15 more
semanticscholar   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Ceftolozane-tazobactam versus meropenem for definitive treatment of bloodstream infection due to extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales (“MERINO-3”): study protocol for a multicentre, open-label randomised non-inferiority trial

Trials, 2021
Background Extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales are common causes of bloodstream infection. ESBL-producing bacteria are typically resistant to third-generation cephalosporins and result in a sizeable economic and ...
Adam G. Stewart, Patrick N. A. Harris, Mark D. Chatfield, Roberta Littleford, David L. Paterson   +4 more
doaj   +1 more source

Consumption of antibiotics within ambulatory care in Malta [PDF]

, 2011
Background: Antibiotic use is recognised as the most important driver for the development of antimicrobial resistance in community pathogens. Surveillance is therefore critical for improvement programmes.
Borg, Michael Angelo, Zarb, Peter
core  

Previous antibiotic exposure increases risk of infection with extended-spectrum-β-lactamase- and AmpC-producing Escherichia coli and Klebsiella pneumoniae in pediatric patients [PDF]

, 2016
The objective of this study was to determine whether antibiotic exposure is associated with extended-spectrum-beta-lactamase- or AmpC-producing Escherichia coli or Klebsiella pneumoniae infections in children.
Adler, Amanda L, Elward, Alexis, Haaland, Wren, Kronman, Matthew P, Miles-Jay, Arianna, Newland, Jason G, Qin, Xuan, Wessman, Scott J, Zaoutis, Theoklis, Zerr, Danielle M, Zhou, Chuan   +10 more
core   +2 more sources

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources