Journal of Medicinal Chemistry, 2022 With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection.
Mihirbaran Mandal +43 more
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Beta-lactamase inhibitors from laboratory to clinic [PDF]
Clinical Microbiology Reviews, 1988 beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed, antimicrobial activity is destroyed. Although beta-lactamases have been identified with clinical failures for over 40 years, enzymes with various abilities to hydrolyze specific
K. Bush
openaire +3 more sources
Synergistic Effect of Clinically Available Beta-Lactamase Inhibitors Combined with Cefiderocol against Carbapenemase-Producing Gram-Negative Organisms. [PDF]
Antibiotics (Basel), 2022 The role of β-lactamases in reduced susceptibility or resistance to cefiderocol has been supported by recent reports. The purpose of this study was to investigate the in vitro impact of clinically available β-lactamase inhibitors on cefiderocol activity ...
Bianco G +7 more
europepmc +2 more sources
Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use. [PDF]
Antibiotics (Basel), 2021 The β-lactams have a central place in the antibacterial armamentarium, but the increasing resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the major threats to public health worldwide.
Carcione D +4 more
europepmc +2 more sources
Docking and Molecular Dynamic of Microalgae Compounds as Potential Inhibitors of Beta-Lactamase [PDF]
International Journal of Molecular Sciences, 2022 Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with β-lactam antibiotics.
Roberto Pestana-Nobles +7 more
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New Delhi Metallo-Beta-Lactamase Inhibitors: A Systematic Scoping Review. [PDF]
J Clin MedNahar L +4 more
europepmc +3 more sources
Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy. [PDF]
Drugs, 2017 Wong D, van Duin D.
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The Rapid CarbaLux Combination Test to Uncover Bacterial Resistance and Heteroresistance Prior to Antibiotic Treatment [PDF]
DiagnosticsBackground/Objectives: In this proof-of-concept study, the objective was to evaluate the phenotypic CarbaLux combination rapid test in terms of guiding the therapy of infections caused by multidrug-resistant Gram-negative bacteria with carbapenemase ...
Hans Rudolf Pfaendler +1 more
doaj +2 more sources
The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U. +3 more
doaj +1 more source
A dataset for machine learning-based QSAR models establishment to screen beta-lactamase inhibitors using the FARM -BIOMOL chemical library. [PDF]
BMC Res NotesPitakbut T +4 more
europepmc +3 more sources