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Metallo Beta Lactamase Enzymes
Indian Journal of MicrobiologyMultidrug resistance has become more common in Gram-negative bacteria, making them one of the emerging public health problems with extremely detrimental effects on the world economy. These drugs are broad-spectrum-lactam antibiotics used as a last-resort treatment against multidrug-resistant microorganisms (MDROs).
Sawsan Mohammed Kareem +2 more
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Zinc Beta Lactamase Superfamily
2013The metallo-beta-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common alpha-beta-beta-alpha fold and share five conserved motifs: Asp84, His116-Xaa-His118-Xaa-Asp120-His121, His196, Asp221 and His263, which are (with the exception of Asp84 ...
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The Journal of antimicrobial chemotherapy, 1989
Inducible beta-lactamases can significantly affect the activities of both beta-lactamase-stable and beta-lactamase-sensitive antibiotics. beta-Lactam antibiotics vary in their ability to induce beta-lactamases. Strong inducers can antagonize the antimicrobial activity of other beta-lactams.
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Inducible beta-lactamases can significantly affect the activities of both beta-lactamase-stable and beta-lactamase-sensitive antibiotics. beta-Lactam antibiotics vary in their ability to induce beta-lactamases. Strong inducers can antagonize the antimicrobial activity of other beta-lactams.
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Cefotetan and beta-lactamases. I. An analysis of the affinity of cefotetan for beta-lactamases.
The Journal of antimicrobial chemotherapy, 1983Cefotetan is a new cephamycin whose interaction with a group of eight beta-lactamases isolated from various Gram-negative bacteria has been studied. Using computerized micro-acidimetry, cefotetan was found to be resistant to the hydrolytic action of various enzymes, including those which actively hydrolyse cefotaxime.
R, Labia +3 more
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beta-lactamases in bacteroides.
Scandinavian journal of infectious diseases. Supplementum, 1978Bacteroides fragilis is responsible for most anaerobic infections in man. Most isolates of B. fragilis show resistance to beta-lactam antibiotics. This resistance might be due to beta-lactamase production or permeability barrier in the cell wall. B. fragilis produce beta-lactamase with mainly cephalosporinase activity. Other Bacteroides species such as
C E, Nord, B, Olsson, K, Dornbusch
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The Chromosomal Beta-Lactamases
1989Virtually all gram-negative bacteria studied to date produce a chromosomal betalactamase. Thus, it is not surprising that there is a great diversity among these enzymes in substrate profile, susceptibility to inhibitors, genetic control of expression and molecular makeup.
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