Results 181 to 190 of about 163,717 (335)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

A Longitudinal Study of E-Cadherin and Beta-Catenin in Progression of Oral Epithelial Dysplasia. [PDF]

J Oral Pathol Med
Yim IS, Zhang L, Rock LD, Rosin MP, Lin I, Laronde DM.   +5 more
europepmc   +1 more source

Correction: Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. [PDF]

Oncotarget, 2023
Leal LF, Bueno AC, Gomes DC, Abduch R, de Castro M, Antonini SR.   +5 more
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Beta-Catenin Mutations Can Impact on the Interplay Between Tumor and Immune Cells and Hepatic Microbiota in Hepatocellular Cancer. [PDF]

J Hepatocell Carcinoma
Ota Y, Driscoll J, Hill AR, Yan IK, Patel T.   +4 more
europepmc   +1 more source

Expression level and prognostic potential of beta-catenin-interacting protein in acute myeloid leukemia. [PDF]

Medicine (Baltimore), 2022
Han H, Zhu B, Xie J, Huang Y, Geng Y, Chen K, Wang W.   +6 more
europepmc   +1 more source

The Inflammatory Cytokine IFNg Regulates Intestinal Epithelial Homeostasis by Controlling the Spatiotemporal Localization of Akt, 14.3.3z and Beta-catenin [PDF]

, 2012
Porfirio Nava, Ryuta Kamekura, Óscar Medina‐Contreras, R. Hamilton, Keli Kolegraff, Stefan Koch, Timothy L. Denning, Charkes Parkos, Asma Nusrat   +8 more
openalex   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Safely Targeting Cancer, the Wound That Never Heals, Utilizing CBP/Beta-Catenin Antagonists. [PDF]

Cancers (Basel)
Higuchi Y, Teo JL, Yi D, Kahn M.
europepmc   +1 more source

Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis. [PDF]

Nat Commun, 2023
Ding D, Blee AM, Zhang J, Pan Y, Becker NA, Maher LJ, Jimenez R, Wang L, Huang H.   +8 more
europepmc   +1 more source