Results 311 to 320 of about 143,797 (322)

Progranulin and beta‐catenin in psoriasis: An immunohistochemical study

Journal of Cosmetic Dermatology, 2019
AbstractBackground/ObjectivesProgranulin (PGRN) is a secreted glycoprotein that was investigated in many skin diseases. It plays an important role in inflammatory response and autophagy which could be mediated through Wnt/β‐catenin pathway. However, the role of PGRN in pathogenesis of psoriasis has not been clearly well‐known.
Azza Gaber Antar Farag, Mohamed Abdalmoneim Shoaib, Rehab Mounir Samaka, Asmaa Gaber Abdou, Marwa Mahmoud Mandour, Reda Abdel Latif Ibrahim   +5 more
openaire   +3 more sources

beta-catenin-cell adhesion and beyond (review)

International Journal of Oncology, 1997
beta-catenin was originally identified as a cytosolic cell protein required for the correct function of the cadherin cell-cell adhesion complex. However, recent studies have identified the presence of intracellular pools of beta-catenin that are cadherin-independent and that beta-catenin is also involved in Wnt-1, src and Tcf-Lef mediated intracellular
Stephen Edward Hiscox, Wen Guo Jiang
openaire   +3 more sources

Beta-catenin is not activated by downregulation of PTEN in osteoblasts

In Vitro Cellular & Developmental Biology - Animal, 2009
Selective knockdown of phosphatase and tensin homolog (PTEN) has been recently shown to increase life long accumulation of bone and its ability to increase osteoblast lifespan. In order to determine how loss of PTEN function affects osteoblast differentiation, we created cell lines with stable knockdown of PTEN expression using short hairpin RNA ...
Jaime Schmidt, Emily Hays, Nalini Chandar   +2 more
openaire   +3 more sources

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

European Journal of Neuroscience, 2001
AbstractThe neuronal cyclin‐dependent kinase p35/cdk5 comprises a catalytic subunit (cdk5) and an activator subunit (p35). To identify novel p35/cdk5 substrates, we utilized the yeast two‐hybrid system to screen for human p35 binding partners. From one such screen, we identified β‐catenin as an interacting protein.
Kesavapany, S, Lau, K F, McLoughlin, D M, Brownlees, J, Ackerley, S, Leigh, P N, Shaw, C E, Miller, C C J   +7 more
openaire   +4 more sources

Pharmacological inhibition of beta-catenin in hepatoblastoma cells

Pediatric Surgery International, 2012
The proto-oncogene beta-catenin is linked to an abnormal activation of the Wnt/beta-catenin-pathway and shows mutations in 50-90 % of hepatoblastoma (HB). Corresponding, the recently published murine orthotopic HB model differs from the former subcutaneous model by nuclear beta-catenin distribution.
Justus Lieber, C. Nagel, Steven W. Warmann, Joerg Fuchs, Julia Wenz, Verena Ellerkamp, Sorin Armeanu-Ebinger   +6 more
openaire   +3 more sources

Characterization of a BETA-Catenin-Associated Kinase

1999
Abstract : Several lines of evidence suggest that accumulation of cytoplasmic Beta-catenin transduces an oncogenic signal. We show that Beta-cantenin is ubiquitinated and degraded by the proteosome and that Beta-cantenin stability is regulated by a diacylglycerol-independent protein kinase C-like kinase activity which is required for Beta-catenin ...
openaire   +1 more source

Beta-Catenin

2012
Ken-Ichi Takemaru, Xingwang Chen, Feng-Qian Li   +2 more
openaire   +1 more source

Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.

Cancer research, 2001
Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin.
BONVINI P., AN W. G., ROSOLEN, ANGELO, NGUYEN P., TREPEL J., GARCIA DE HERREROS A., DUNACH M., NECKERS L. M.   +7 more
openaire   +2 more sources

Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Beta-catenin Overexpression and an Actionable Beta-catenin Mutation

Journal of Neurological Surgery Part B: Skull Base, 2016
Chad Brenner, Erin L. McKean, Jacques E. Nör, Sarah J. Burgin, Andrew C. Birkeland, Scott A. McLean, Jonathan B. McHugh   +6 more
openaire   +2 more sources

Beta-Catenin in Squamous Cell Carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2005
S.C.O.M. Sousa, D.S. Pinto, Fábio Daumas Nunes   +2 more
openaire   +2 more sources