Frontiers in Neuroscience, 2016 The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma ...
Alexandre Vallée, Y. Lecarpentier
semanticscholar +1 more source
Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat [PDF]
, 2010 The structural integrity of cardiac cells is maintained by the Ca2+-dependent homophilic cell-cell adhesion of cadherins. N-cadherin is responsible for this adhesion under normal physiological conditions.
Baker, Andrew +4 more
core +3 more sources
Target specific peptide design using latent space approximate trajectory collector [PDF]
arXiv, 2023 Despite the prevalence and many successes of deep learning applications in de novo molecular design, the problem of peptide generation targeting specific proteins remains unsolved. A main barrier for this is the scarcity of the high-quality training data. To tackle the issue, we propose a novel machine learning based peptide design architecture, called
arxiv
BMC Cancer, 2016 Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. Angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer.
Ningning Liu +6 more
semanticscholar +1 more source
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2008 BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff +6 more
doaj +1 more source
Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin [PDF]
, 2014 The susceptibility of brain to secondary formation from lung cancer primaries is a well-known phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is largely unknown.
Beroš, Vili +5 more
core +2 more sources
AQP1 Is Not Only a Water Channel: It Contributes to Cell Migration through Lin7/Beta-Catenin [PDF]
PLoS ONE 4(7): e6167, 2009, 2013 Background: AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues. Recent papers showed that during angiogenesis, AQP1 is expressed preferentially by microvessels, favoring angiogenesis via the increase of permeability In particular, in AQP1 null mice, endothelial cell migration is impaired without ...
arxiv +1 more source
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]
PLoS ONE, 2009 Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee +3 more
doaj +1 more source
Diagnostic Pathology, 2011 Background Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer.
Cheng Hongxia +3 more
doaj +1 more source
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. [PDF]
, 2017 β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic
Bhattacharyya, A +7 more
core +1 more source