Results 121 to 130 of about 2,087,290 (305)

Regulation of beta cell replication

Molecular and Cellular Endocrinology, 2009
Beta cell mass, at any given time, is governed by cell differentiation, neogenesis, increased or decreased cell size (cell hypertrophy or atrophy), cell death (apoptosis), and beta cell proliferation. Nutrients, hormones and growth factors coupled with their signalling intermediates have been suggested to play a role in beta cell mass regulation.
Lee, Ying C, Nielsen, Jens Høiriis
openaire   +4 more sources

Predominant utilization of V beta 8+ T cell receptor genes in the H-2Ld- restricted cytotoxic T cell response against the immediate-early protein pp89 of the murine cytomegalovirus [PDF]

, 1989
Cytotoxic T cell responses to the murine Cytomegalovirus (MCMV) were elicited in BALB/c mice (H-2d) by infectious virus. Eight days after infection, MCMV-primed local lymph node T cells were either depleted for T cells expressing a V beta 8+ TCR or ...
Eichmann, K., Koszinowski, Ulrich H., Melchers, I., Roedewald, H. R.   +3 more
core  

Degrees of Freedom and Achievable Rate of Wide-Band Multi-cell Multiple Access Channels With No CSIT

, 2017
This paper considers a $K$-cell multiple access channel with inter-symbol interference. The primary finding of this paper is that, without instantaneous channel state information at the transmitters (CSIT), the sum degrees-of-freedom (DoF) of the ...
Jeon, Yo-Seb, Lee, Namyoon, Tandon, Ravi
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Beta cells deficient for Renalase counteract autoimmunity by shaping natural killer cell activity

Frontiers in Immunology
Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing pancreatic beta cells. Recent advancements in the technology of generating pancreatic beta cells from human pluripotent stem cells (SC-beta cells) have facilitated the
Kevin Bode, Kevin Bode, Kevin Bode, Siying Wei, Siying Wei, Isabella Gruber, Jian Li, Jian Li, Stephan Kissler, Stephan Kissler, Stephan Kissler, Peng Yi, Peng Yi, Peng Yi   +13 more
doaj   +1 more source

A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif [PDF]

, 2010
The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg, Vicenta Salvador-Recatala   +1 more
core   +1 more source

Neuromorphometric characterization with shape functionals

, 2003
This work presents a procedure to extract morphological information from neuronal cells based on the variation of shape functionals as the cell geometry undergoes a dilation through a wide interval of spatial scales.
A. Mizrahi, A. van Ooyen, A.X. Falcao, B.B. Boycott, C. Koch, Esmerindo de Sousa Bernardes, G.A. Ascoli, H. Wassle, H.G. Krapp, K. Michelsen, K. Michelsen, K. Morigiwa, K.L. Whitford, K.R. Mecke, L. da F Costa, L. da F. Costa, L. da F. Costa, L. da F. Costa, Luciano da Fontoura Costa, Marconi Soares Barbosa, R.M. Cesar, R.M. Cesar, Y. Fukuda   +22 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Author Correction: The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis

Scientific Reports, 2022
Somik Chatterjee, Hongshan Yin, Weini Li, Jeongkyung Lee, Vijay K. Yechoor, Ke Ma   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source