Results 71 to 80 of about 2,087,290 (305)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A role for von Hippel-Lindau protein in pancreatic beta-cell function. [PDF]
, 2009 ObjectiveThe Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.
Cano, David A +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Modulating light level patterns reduces rest/activity disruption associated with shiftwork
npj Biological Timing and SleepLong-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice ...
Varun Mandi +8 more
doaj +1 more source
Type 1 diabetes pathogenesis - Prevention???
Indian Journal of Endocrinology and Metabolism, 2015 Pathogenesis of type 1 diabetes is multi-faceted, including, autoimmunity, genetics and environment. Autoimmunity directed against pancreatic islet cells results in slowly progressive selective beta-cell destruction ("Primary autoimmune insulitis ...
C S Muralidhara Krishna, S Srikanta
doaj +1 more source
Beta Living through Alpha Cells [PDF]
Cell Stem Cell, 2019 Recently in Nature, Furuyama et al. (2019) provide evidence for lineage plasticity in the human endocrine pancreas, demonstrating that α cells derived from adult human pancreatic islets can be reprogrammed to become glucose-responsive, insulin-secreting β-like cells that are capable of reversing diabetes in mouse models.
Sophie, Patzek, Julie B, Sneddon
openaire +2 more sources
Beta Oscillations and Hippocampal Place Cell Learning during Exploration of Novel Environments [PDF]
, 2008 Berke et al. (2008) reported that beta oscillations occur during the learning of hippocampal place cell receptive fields in novel environments. Place cell selectivity can develop within seconds to minutes, and can remain stable for months. Paradoxically,
Grossberg, Stephen
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Disease Models & Mechanisms, 2020 Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and progression of multiple inflammatory diseases.
Sara Ibrahim +5 more
doaj +1 more source
The Pancreatic Beta Cell: Editorial
Biomolecules, 2023 Pancreatic beta cells play a critical role in maintaining glucose homeostasis by serving as the primary source of insulin [...]
openaire +3 more sources