Betatrophin: a hormone that controls pancreatic β cell proliferation.
Cell, 2013 Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion.
Yi, Peng, Park, Ji Sun, Melton, Douglas
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Regulators of Mouse and Human Beta Cell Proliferation [PDF]
, 2013 Diabetes mellitus is an increasingly prevalent metabolic disorder that is estimated to affect over 300 million people by 2025. Common to either type 1 or type 2 diabetes is a progressive inadequacy of functional beta-cell mass.
Jiao, Yang
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Betatrophin Fuels β Cell Proliferation: First Step toward Regenerative Therapy? [PDF]
Cell Metabolism, 2013 Millions of diabetic patients are waiting for better treatment options, ideally by replenishing the lost or dysfunctional insulin-producing β cell mass. Yi et al. (2013) now identify Betatrophin, a hormone that specifically increases β cell proliferation with promising therapeutic potential.
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Increased serum levels of betatrophin in pancreatic cancer-associated diabetes
Oncotarget, 2016 Long-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer. Betatrophin, a novel liver-derived hormone, promotes β-cell proliferation and improves glucose intolerance. However, the relationship between betatrophin and PDAC-associated diabetes is not fully understood.
Susanto, Hendra +5 more
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Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome [PDF]
, 2016 To evaluate the status of serum betatrophin levels and potential relations between metabolic parameters and betatrophin levels in patients with polycystic ovary syndrome. We included patients newly diagnosed with PCOS in our study.
Asik, M. +6 more
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Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue [PDF]
The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter is the ...
Blanco, Enrique J. +8 more
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Plasma Betotrophin Levels of Patients with Subclinical Hypothyroidism
Endocrinology Research and Practice, 2018 Introduction: Since betatrophin has an effect on both lipid and glucose homeostasis, its thought to be valuable for further researches as a promising metabolic regulator.
Rıfkı Üçler +2 more
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RESEARCH COMMUNICATIONS OF THE 33rd ECVIM‐CA CONGRESS
Journal of Veterinary Internal Medicine, Volume 38, Issue 1, Page 730-863, January/February 2024.
wiley +1 more source
UEG Week 2019 Poster Presentations
, 2019 United European Gastroenterology Journal, Volume 7, Issue S8, Page 189-1030, October 2019.
wiley +1 more source
The Relationship of Betatrophin and Kisspeptin with Related Hormones in Women Newly Diagnosed with Polycystic Ovary Syndrome [PDF]
متلازمة المبيض متعدد الأكياس واحدة من أكثر اضطرابات هرمونات الغدد الصماء انتشارا التي تصيب النساء في سن الإنجاب، وهي مصدر أساسي لها علاقة بالصحة العامة التي تؤدي إلى خلل في الأنظمة التناسلية والأيضية والنفسية، يعد انقطاع الإباضة الذي يلعب دورا ...
AL-Attar, Noor E. +3 more
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