Results 161 to 170 of about 2,690,513 (210)
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A practical synthesis of betulinic acid
Tetrahedron Letters, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rene Csuk +2 more
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Studies on Solvatomorphism of Betulinic Acid
Journal of Pharmaceutical Sciences, 2014Five solvates of betulinic acid with dimethyl sulfoxide (I), methanol (II), ethanol (III), isopropyl alcohol (IV), and 2-butanol (V) have been described in this work. Methods of X-ray crystallography, thermal analysis, and Fourier transform infrared spectroscopy were introduced for solvatomorphic identifications and characterizations.
Xiaoying, Wang +4 more
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Microbial Pathogenesis, 2017
Contribution of reactive oxygen species and oxidative stress in the antibacterial activities of betulin, betulinic acid and ursolic acid against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was investigated. The minimum inhibitory concentrations of betulin, betulinic acid and ursolic acid against E. coli, P.
H O B, Oloyede +3 more
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Contribution of reactive oxygen species and oxidative stress in the antibacterial activities of betulin, betulinic acid and ursolic acid against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was investigated. The minimum inhibitory concentrations of betulin, betulinic acid and ursolic acid against E. coli, P.
H O B, Oloyede +3 more
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Selective Oxidation of Betulin for the Preparation of Betulinic Acid, an Antitumor Compound.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Pichette, André +5 more
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Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides
Steroids, 2022Betulin and betulinic acid derived 30-oxo-amides were prepared by hydroboration, subsequent oxidation and amidation; these novel compounds were screened for their cytotoxic activity by SRB assays. All of the compounds showed significant cytotoxic activity for different human tumor cell lines.
Kozubek, Marie +5 more
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Synthesis and Anticancer Activity of Novel Betulinic acid and Betulin Derivatives
Archiv der Pharmazie, 2010AbstractA series of novel betulinic acid derivatives 3–11 and betulin derivatives 12–17 were synthesized. The compounds were characterized by the means of 1H‐ and 13C‐NMR spectroscopy as well as mass spectrometry. The compounds have been tested on ten tumor cell lines of different histogenic origin.
Harish, Kommera +3 more
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Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
Bioorganic & Medicinal Chemistry, 2012The aim of this work was to synthesize a set of heterocyclic derivatives of lupane, lup-20(29)-ene, and 18α-oleanane, and to investigate their cytotoxic activities. Some of those heterocycles were previously known in the oleanane (allobetulin) group; however, to our knowledge the syntheses and biological activities of lupane heterocycles have not been ...
Milan, Urban +4 more
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Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity
Bioorganic & Medicinal Chemistry Letters, 2010Synthesis and antiproliferative activity of eight new derivatives of betulinic acid (1) and betulin (2) are described. The compounds were tested against fifteen tumor cell lines. The toxicity against normal human fibroblasts and the mode of cell death on lung cancer cell line induced by the most active compounds 9 (bis(ethylcarbamate)betulin) and 11 (3-
Harish, Kommera +6 more
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Targeting Cancer by Betulin and Betulinic Acid
2012Because of their selective cytotoxicity against many different tumor cell and their favorable therapeutic index, betuline, betulinic acid and many of their derivatives are very promising chemotherapeutic agents for the treatment and prevention of several diseases especially of cancer.
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Antiprotozoal activity of Betulinic acid derivatives
Phytomedicine, 2010Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity.
D B, Domínguez-Carmona +7 more
exaly +3 more sources