Results 171 to 180 of about 2,690,513 (210)
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Applied Microbiology and Biotechnology, 2014
Betulinic acid is a plant-based triterpenoid that has been recognized for its antitumor and anti-HIV activities. The level of betulinic acid in its natural hosts is extremely low. In the present study, we constructed betulinic acid biosynthetic pathway in Saccharomyces cerevisiae by metabolic engineering.
Jing, Li, Yansheng, Zhang
exaly +3 more sources
Betulinic acid is a plant-based triterpenoid that has been recognized for its antitumor and anti-HIV activities. The level of betulinic acid in its natural hosts is extremely low. In the present study, we constructed betulinic acid biosynthetic pathway in Saccharomyces cerevisiae by metabolic engineering.
Jing, Li, Yansheng, Zhang
exaly +3 more sources
Biotransformation of betulinic and betulonic acids by fungi
Phytochemistry, 2007Betulinic acid (1), a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. The closely related, betulonic acid (2) also has similar properties. In order to obtain derivatives potentially useful for detailed pharmacological studies, both compounds ...
Denise Z L, Bastos +3 more
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Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
The Journal of Membrane BiologyThe purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phase behaviour and bilayer packing in pulmonary surfactant membranes. Therefore, the interaction of these triterpenoids with dipalmitoylphosphatidylcholine (DPPC) bilayers is studied by differential scanning calorimetry (DSC ...
Altunayar Unsalan, Cisem, Unsalan, Ozan
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Journal of Natural Products, 2019
Naturally occurring pentacyclic lupane triterpenoids such as betulin (1) or betulinic acid (2) and their synthetic derivatives display a broad spectrum of biological activities and, therefore, have been the subject of great interest. However, the use of these compounds as potential therapeutic agents is limited by their low bioavailability, high ...
Mirosława Grymel +2 more
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Naturally occurring pentacyclic lupane triterpenoids such as betulin (1) or betulinic acid (2) and their synthetic derivatives display a broad spectrum of biological activities and, therefore, have been the subject of great interest. However, the use of these compounds as potential therapeutic agents is limited by their low bioavailability, high ...
Mirosława Grymel +2 more
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Therapeutic applications of betulinic acid nanoformulations
Annals of the New York Academy of Sciences, 2018AbstractBetulinic acid (BA), a naturally occurring plant‐derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad‐spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half‐life in vivo, which limit ...
Ankit, Saneja +5 more
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Synthesis and Pharmacological Activity of Betulin Esters, Betulinic Acids and Allobetulin.
ChemInform, 2006AbstractFor Abstract see ChemInform Abstract in Full Text.
O. B. Flekhter +6 more
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Synthesis and Pharmacological Activity of Betulin, Betulinic Acid, and Allobetulin Esters
Pharmaceutical Chemistry Journal, 2005A series of new triterpene hemisuccinates, hemiphthalates and nicotinates have been obtained with 52 – 95% yields via reactions of monoacetates of betulin, betulinic acid, and allobetulin with succinic and phthalic anhydrides and with nicotinic acid chloroanhydride.
O. B. Flekhter +6 more
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Synthesis of Ibuprofen Conjugates with Betulin, Allobetulin, and Betulinic Acid
Chemistry of Natural Compounds, 2022M. P. Yakovleva +7 more
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Synthesis of Betulonic and Betulinic Acids from Betulin
Chemistry of Natural Compounds, 2018M. P. Yakovleva +3 more
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