Results 111 to 120 of about 41,817 (145)

Novel <i>ATOH7</i> mutation and structural characterization in families with optic nerve hypoplasia. [PDF]

open access: yesInt J Ophthalmol
Ullah MI   +9 more
europepmc   +1 more source

bHLH–PAS proteins in cancer

Nature Reviews Cancer, 2013
Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcription factors that sense and respond to environmental signals (such as pollutants) or to physiological signals (for example, hypoxia and circadian rhythms) through their two PAS domains.
Bersten, D.   +3 more
openaire   +3 more sources

Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist

Science, 1996
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome.
D B, Spicer   +3 more
openaire   +2 more sources

Hey bHLH Transcription Factors

2014
Hey bHLH transcription factors are direct targets of canonical Notch signaling. The three mammalian Hey proteins are closely related to Hes proteins and they primarily repress target genes by either directly binding to core promoters or by inhibiting other transcriptional activators.
David, Weber   +2 more
openaire   +2 more sources

Hey bHLH Factors in Cardiovascular Development

Pediatric Cardiology, 2009
The Notch pathway is now firmly established as a key signaling system for embryonic cardiovascular development as well as some adult pathologies in vertebrates. We have identified Hey bHLH transcriptional repressors as critical, but partly redundant transducers of these signals.
Cornelia, Wiese   +2 more
openaire   +2 more sources

Duplication of an amphioxus myogenic bHLH gene is independent of vertebrate myogenic bHLH gene duplication

Gene, 1996
Gene duplication is thought to be a major genetic change that may have permitted the evolution of vertebrates from invertebrates. The myogenic genes encode basic helix-loop-helix (bHLH) transcriptional factors essential for the formation of skeletal muscle. The invertebrate genome contains only a single myogenic bHLH gene, whereas the vertebrate genome
I, Araki, K, Terazawa, N, Satoh
openaire   +2 more sources

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