Results 121 to 130 of about 41,817 (145)

Retinal cell fate determination and bHLH factors

Seminars in Cell & Developmental Biology, 2004
Retinal development is controlled antagonistically by multiple basic helix-loop-helix (bHLH) transcriptional activators and repressors. bHLH repressors suppress bHLH activators and promote maintenance of progenitors and generation of glial cells. In contrast, bHLH activators override activities of bHLH repressors and promote neuronal differentiation ...
Jun, Hatakeyama, Ryoichiro, Kageyama
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bHLH Transcription factors and mammalian neuronal differentiation

The International Journal of Biochemistry & Cell Biology, 1997
The basic helix-loop-helix (bHLH) factor Mash1 is expressed in the developing nervous system. Null mutation of Mash1 results in loss of olfactory and autonomic neurons and delays differentiation of retinal neurons, indicating that Mash1 promotes neuronal differentiation.
R, Kageyama, M, Ishibashi, K, Takebayashi, K, Tomita   +3 more
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bhlh Proteins

1998
Abstract As described in Chapter 3, the basic helix-loop-helix (bHLH) proteins are a large superfamily of dimeric transcription factors in which the HLH motif mediates protein dimerization and the basic domain mediates DNA binding. In some bHLH families, such as the myogenic bHLH family consisting of MYOD, MYOGENIN, MYFS, and MRF4 ...
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bHLH Proteins and Their Role in Somitogenesis

2008
The most obvious manifestation of the existence of a segmented, or metameric, body plan in vertebrate embryos is seen during the formation of the somites. Somites are transient embryonic structures formed in a progressive manner from a nonsegmented mesoderm in a highly regulated process called somitogenesis.
Maroto, Miguel, Iimura, Tadahiro, Dale, J. Kim, Bessho, Yasumasa   +3 more
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The functions of bHLH proteins

1998
Abstract Most known bHLH proteins are transcriptional regulators. That is, they are proteins that are able to alter the genetic programme of cells by repressing or activating specific genes, often genes involved in control of growth and differentiation. Not surprisingly, therefore, inappropriate expression of genes encoding both bHLH and
Trevor D Littlewood, Gerard I Evan
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Proneural bHLH Genes in Development and Disease

2014
Proneural genes encode evolutionarily conserved basic-helix-loop-helix transcription factors. In Drosophila, proneural genes are required and sufficient to confer a neural identity onto naïve ectodermal cells, inducing delamination and subsequent neuronal differentiation. In vertebrates, proneural genes are expressed in cells that already have a neural
Carol, Huang, Jennifer A, Chan, Carol, Schuurmans   +2 more
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Asymmetric DNA Binding by A Homodimeric bHLH Protein

Biochemistry, 2000
Protein-DNA interactions that lie outside of the core recognition sequence for the Drosophila bHLH transcription factor Deadpan (Dpn) were investigated using minor groove binding pyrrole-imidazole polyamides. Electrophoretic mobility shift assays and DNase I footprinting demonstrate that hairpin polyamides bound immediately upstream, but not ...
Winston, Rachel L., Ehley, Jennifer A., Baird, Eldon E., Dervan, Peter B., Gottesfeld, Joel M.   +4 more
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Characterization of hey bHLH genes in teleost fish

Development Genes and Evolution, 2003
Hairy-related basic helix-loop-helix (bHLH) transcription factors are targets of Delta-Notch signaling and represent essential components for a number of cell fate decisions during vertebrate embryogenesis. Hey genes encode a subfamily of hairy-related proteins that have been implicated in processes like somitogenesis, blood vessel and heart ...
Christoph, Winkler, Harun, Elmasri, Barbara, Klamt, Jean-Nicolas, Volff, Manfred, Gessler   +4 more
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bHLH proteins know when to make a stoma

Trends in Plant Science, 2007
In Arabidopsis thaliana, stomata develop through a stereotypical pattern of cell divisions. Three recent publications demonstrate that three bHLH proteins act successively in such lineages to drive the formation of stomata. SPEECHLES drives the division that initiates the stomatal-cell lineage.
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The bHLH genes in neural development.

The International journal of developmental biology, 1998
Groups of genes sharing similar motifs may be used at different steps of a same developmental process. In this review, we discuss the significance of this phenomenon in the case of the basic Helix-Loop-Helix (bHLH) proteins that are involved at different steps of the development of the peripheral nervous system (PNS) of Drosophila.
C, Dambly-Chaudière, M, Vervoort
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