Results 131 to 140 of about 32,113 (221)

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

A Case of IDH‐Mutant Astrocytoma Harboring an IDH2 R172_H173delinsSN Variant

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT IDH‐mutant gliomas most commonly harbor the canonical IDH1 p.R132H mutation, followed by less common mutations involving IDH1 p.R132 or IDH2 p.R172 codons. We present a case of a 32‐year‐old male found to have a left temporal brain tumor with regional enhancement on brain MRI, for which he underwent resection.
Thomas Auen, Jie Chen, Nicole Shonka, Sahara Cathcart   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, Volume 20, Issue 3, Page 688-708, March 2026.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

Transposable elements: Functional aspects and applications as drivers of crop innovation

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros, José Ribamar Costa Ferreira‐Neto, Jarbson Henrique Oliveira Silva, Cinthia Carla Claudino Grangeiro Nunes, Ana Luíza Trajano Mangueira de Melo, Ayug Bezerra Lemos, Madson Allan de Luna‐Aragão, Agnes Angélica Guedes de Barros, Simon Orozco‐Arias, Eliseu Binneck, Francismar Correa Marcelino‐Guimarães, Ana Cristina Brasileiro‐Vidal, Ana Maria Benko‐Iseppon   +12 more
wiley   +1 more source

Exploring Transcriptomic Microsatellite Markers in Hydrangea petiolaris (Hydrangeaceae): A Resource for Population Genetics and Functional Genomic Insights

Ecology and Evolution, Volume 16, Issue 3, March 2026.
This study analyzed the genetic population structure of Hydrangea petiolaris using 28 SSR markers. Distinct genetic clusters were identified, providing valuable insights for the evolution and conservation. Specifically, STRUCTURE analysis revealed clear genetic differentiation, contributing to our understanding of the species' genetic diversity ...
Seongjun Park, Sumi Choi, Saeyeon Hwang, Eun‐Mi Lee, SeonJoo Park   +4 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Genome-wide analysis of the Tritipyrum bHLH gene family and the response of TtbHLH310 in salt-tolerance. [PDF]

BMC Genomics
Li K, Cong C, Wang Y, Zhang H, Li Y, Xiao J, Ding Y, Zhang L.   +7 more
europepmc   +1 more source