Results 131 to 140 of about 11,411 (182)

Allosteric transition: a comparison of two models [PDF]

, 2013

core   +1 more source

Biased agonism at free-fatty acid receptor-4 (FFA4/GPR120). [PDF]

Pharmacol Ther
Teyani RL, Moniri NH.
europepmc   +1 more source

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities. [PDF]

Protein Sci
Lipinski B, Unmuth L, Arras P, Endruszeit R, Becker S, Rödel JM, Scheller J, Pudewell S, Floss DM, Krah S, Harwardt J, Doerner A, Helming L, Xu C, Menrad A, Evers A, Kolmar H, Elter D, Pekar L, Zielonka S.   +19 more
europepmc   +1 more source

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

, 2023
Xiao J, Eid LE, Buenaventura T, Boutry R, Bonnefond A, Jones B, Rutter GA, Froguel P, Tomas A.   +8 more
europepmc   +1 more source

Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. [PDF]

Cell Res
Sun D, Li X, Yuan Q, Wang Y, Shi P, Zhang H, Wang T, Sun W, Ling S, Liu Y, Lai J, Xie W, Yin W, Liu L, Xu HE, Tian C.   +15 more
europepmc   +1 more source

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

, 2023
Yadav MK, Sarma P, Ganguly M, Mishra S, Maharana J, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK.   +13 more
europepmc   +1 more source

TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization. [PDF]

PLoS One
Kim D, Strzelinski HR, Liggett SB.
europepmc   +1 more source

Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A_2A receptor. [PDF]

Comput Struct Biotechnol J, 2020
Navarro G, Gonzalez A, Campanacci S, Rivas-Santisteban R, Reyes-Resina I, Casajuana-Martin N, Cordomí A, Pardo L, Franco R.   +8 more
europepmc   +1 more source

Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases. [PDF]

Am J Respir Cell Mol Biol
Shah SD, Deshpande DA.
europepmc   +1 more source

GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. [PDF]

Commun Biol
Matthees ESF, Filor JC, Jaiswal N, Reichel M, Youssef N, D'Uonnolo G, Szpakowska M, Drube J, König GM, Kostenis E, Chevigné A, Godbole A, Hoffmann C.   +12 more
europepmc   +1 more source