Results 141 to 150 of about 185,950 (192)

Hepatocyte-independent PAR1-biased signaling controls liver pathology in experimental obesity. [PDF]

J Thromb Haemost
Cline H, Wei Z, Groeneveld DJ, Hix JML, Xu X, Flick MJ, Palumbo JS, Poole LG, Dockendorff C, Griffin JH, Luyendyk JP.   +10 more
europepmc   +1 more source

GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization. [PDF]

Sci Signal
Gardner J, Eiger DS, Hicks C, Choi I, Pham U, Chundi A, Namjoshi O, Rajagopal S.   +7 more
europepmc   +1 more source

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. [PDF]

Science, 2020
Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO.   +10 more
europepmc   +1 more source

β-arrestin biased signaling is not involved in the hypotensive actions of 5-HT₇ receptor stimulation: use of Serodolin. [PDF]

Pharmacol Res
Watts SW, Garver H, Morisset-Lopez S, Suzenet F, Fink GD.   +4 more
europepmc   +1 more source

Biased signaling and L1 penalization

, 2017
openaire   +2 more sources

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A community Biased Signaling Atlas

Nature Chemical Biology, 2023
Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas.org) provides a community hub with data and tools to advance this paradigm, which may yield safer and more potent drugs.
Jimmy Caroli, Alibek Mamyrbekov, Kasper Harpsøe, Sahar Gardizi, Linda Dörries, Eshan Ghosh, Alexander S. Hauser, Albert J. Kooistra, David E. Gloriam   +8 more
openaire   +3 more sources

Arresting Developments in Biased Signaling

Trends in Pharmacological Sciences, 2020
The ability to design 'biased' drugs that selectively activate G protein-coupled receptor (GPCR) signaling pathways beneficial in treating a disease, while limiting their side effects, is of broad significance. Lee et al. move us a step closer to this important goal by identifying structural differences in the β1-adrenoceptor in complex with β-arrestin
Sungsoo M, Yoo, Anshul, Bhardwaj, Jeffrey L, Benovic   +2 more
openaire   +2 more sources

Biased signaling as allosteric probe dependence

Cellular Signalling, 2021
Signaling 'bias' is a phenomenon whereby the natural allosteric probe dependence of seven transmembrane receptors allows different receptor conformations (stabilized by different agonists) to activate some signaling pathways (coupled to pleiotropically coupled receptors) more than others at the expense of those other pathways.
openaire   +2 more sources