Results 151 to 160 of about 185,950 (192)
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Signal Detection Measures Cannot Distinguish Perceptual Biases from Response Biases
Perception, 2015A common conceptualization of signal detection theory (SDT) holds that if the effect of an experimental manipulation is truly perceptual, then it will necessarily be reflected in a change in d' rather than a change in the measure of response bias.
Jessica K, Witt +3 more
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Biasing GPCR Signaling from Inside
Science Signaling, 2014Strategies that target the intracellular domain of G protein–coupled receptors may enable development of new intracellular biased signaling modulators.
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Probing Biased Signaling in Chemokine Receptors
2016The chemokine system mediates leukocyte migration during homeostatic and inflammatory processes. Traditionally, it is described as redundant and promiscuous, with a single chemokine ligand binding to different receptors and a single receptor having several ligands.
Amarandi, Roxana Maria +3 more
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Functional Selectivity and Biased Receptor Signaling
The Journal of Pharmacology and Experimental Therapeutics, 2011With the emergence of information describing functional selectivity and biased agonists and antagonists has come a lack of confidence in "one size fits all" assays for detection of agonism. Seven-transmembrane receptors are pleiotropic with respect to the signaling protein to which they couple in a cell, and many conformations of the receptor can be ...
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Histamine H2 Receptor Biased Signaling Methods
2017Fil: Fernandez, Natalia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Farmacologicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica.
Fernandez, Natalia Cristina +3 more
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Quantifying Biased β-Arrestin Signaling
2013It is now established that agonists do not uniformly activate pleiotropic signaling mechanisms initiated by receptors but rather can bias signals according to the unique receptor conformations they stabilize. One of the important emerging signaling systems where this can occur is through β-arrestin.
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Biased signalling in follicle stimulating hormone action
Molecular and Cellular Endocrinology, 2014Follicle-stimulating hormone (FSH) plays a crucial role in the control of reproduction by specifically binding to and activating a membrane receptor (FSHR) that belongs to the G protein-coupled receptor (GPCR) family. Similar to all GPCRs, FSHR activation mechanisms have generally been viewed as a two-state process connecting a unique FSH-bound active ...
Landomiel, Flavie +8 more
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Identification of Frequency of Biased Harmonic Signal
European Journal of Control, 2007zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aranovskiy, Stanislav +4 more
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Self-fulfilling currency attacks with biased signals
Journal of Policy Modeling, 2007Abstract S. Morris and H.S. Shin [(1998). Unique equilibrium in a model of self-fulfilling currency attacks. American Economic Review, 88(3), 587–597] have shown in a model of self-fulfilling currency crises that when removing the assumption of common knowledge among speculators multiplicity of equilibria disappears.
DELLA POSTA, POMPEO, CHELI, BRUNO
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Emerging structural insights into biased GPCR signaling
Trends in Biochemical Sciences, 2014The discovery of biased signaling at G protein-coupled receptors (GPCRs), the largest class of cell surface receptors and primary drug targets for numerous human diseases, has redefined the classical concepts of receptor pharmacology. It not only highlights the depth of signaling diversity within the GPCR system, but also offers possibilities for novel
Arun K, Shukla +2 more
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