Results 41 to 50 of about 185,950 (192)
FEBS Open Bio, 2022 EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways.
Keijo Fukushima +4 more
doaj +1 more source
Influence of sex differences on microRNA gene regulation in disease. [PDF]
, 2014 Sexual dimorphism is observed in most human diseases. The difference in the physiology and genetics between sexes can contribute tremendously to the disease prevalence, severity, and outcome.
Eghbali, Mansoureh, Sharma, Salil
core +1 more source
Biased Receptor Signaling in Drug Discovery [PDF]
Pharmacological Reviews, 2019 A great deal of experimental evidence suggests that ligands can stabilize different receptor active states that go on to interact with cellular signaling proteins to form a range of different complexes in varying quantities. In pleiotropically linked receptor systems, this leads to selective activation of some signaling pathways at the expense of ...
openaire +2 more sources
Biased agonism: the quest for the analgesic holy grail
PAIN Reports, 2018 . Opioids alleviate pain, but adverse effects severely limit their usefulness. To solve this problem, biased ligands favoring 1 signaling pathway downstream of the μ-opioid receptor over another are being developed.
M. Alexander Stanczyk, Ram Kandasamy
doaj +1 more source
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas [PDF]
, 2016 Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression.
Cassidy, A.P. +3 more
core +3 more sources
An Online Biased Signaling Atlas
, 2022 Abstract Biased signaling is a paradigm in signal transduction whereby hormones, probes, or drugs bind the same receptor but engage different intracellular signaling pathways leading to distinct functional outcomes. Whereas there is a wealth of knowledge of bias signaling, it is scattered throughout literature and the vast majority of signaling
Jimmy Caroli +8 more
openaire +1 more source
Data + pilot biases in modern GNSS signals
GPS Solutions, 2023 AbstractWhile traditional GNSS signals are always modulated with navigation data, various modern signals provide a distinct pilot channel without data modulation to support long coherent integration times. Intra-signal biases between the data and pilot components of such signals are evaluated for satellites of the GPS, Galileo, BeiDou-3, and QZSS ...
Montenbruck, Oliver +2 more
openaire +1 more source
FASEB BioAdvances, 2022 The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways.
Emilio Y. Lucero‐Garcia Rojas +4 more
doaj +1 more source
Physical constraints on accuracy and persistence during breast cancer cell chemotaxis [PDF]
, 2019 Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer metastasis.
Han, Bumsoo +4 more
core +4 more sources
MoleculesG-protein coupled receptors (GPCRs) are the largest family of membrane proteins engaged in transducing signals from the extracellular environment into the cell.
Shaima Hashem +2 more
doaj +1 more source