Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6
Cells, 2023 GPR126/ADGRG6, a member of the adhesion G-protein-coupled receptor family, balances cell differentiation and proliferation through fine-tuning of intracellular cAMP levels, which is achieved through coupling to Gs and Gi proteins.
Caroline Wilde +5 more
doaj +1 more source
Tuning Biased GPCR Signaling for Physiological Gain [PDF]
Cell, 2017 Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.
Skylar, Spangler, Michael R, Bruchas
openaire +2 more sources
Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]
, 2015 Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P +8 more
core +2 more sources
β-Arrestin and dishevelled coordinate biased signaling [PDF]
Proceedings of the National Academy of Sciences, 2011 The adaptor proteins β-arrestins 1 and 2 are ubiquitously expressed and were originally discovered for desensitizing G protein-mediated signal transduction by the cell-surface seven-transmembrane receptors (7TMRs or GPCRs) (1). 7TMRs constitute the largest family of cell-surface receptors, and their signaling regulates almost every aspect of mammalian ...
Gunnar, Schulte, Sudha K, Shenoy
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Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep [PDF]
, 2017 In Caenorhabditis elegans, Notch signaling regulates developmentally timed sleep during the transition from L4 larval stage to adulthood (L4/A) . To identify core sleep pathways and to find genes acting downstream of Notch signaling, we undertook the ...
Hart, Anne C +4 more
core +3 more sources
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
core +2 more sources
Ligand bias underlies differential signaling of multiple FGFs via FGFR1
eLifeThe differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development.
Kelly Karl +8 more
doaj +1 more source
Deciphering Complex Interactions in Bioactive Lipid Signaling
Molecules, 2023 Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been
Mauro Maccarrone
doaj +1 more source
β-Arrestin–biased signaling mediates memory reconsolidation [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance β-Adrenergic receptors (β-ARs) are hormone and neurotransmitter receptors. The data we present in this paper challenge the assumption that memory reconsolidation is governed by the traditional β-AR/G protein signaling pathway.
Xing, Liu +6 more
openaire +2 more sources
Structural Basis of the Diversity of Adrenergic Receptors
Cell Reports, 2019 Summary: Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them.
Lu Qu +11 more
doaj +1 more source