Results 71 to 80 of about 185,950 (192)
Frontiers in Chemistry, 2020 As a key cytokine mediator of inflammation, interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and activates various downstream signaling mediators, including NF-κB, which is required for immune vigilance and cellular protection.
Azade Geranurimi +14 more
doaj +1 more source
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]
, 2019 Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen +6 more
core
The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]
, 2020 The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III +2 more
core +1 more source
Experimental Realization of Device-Independent Quantum Randomness Expansion
, 2021 Randomness expansion where one generates a longer sequence of random numbers from a short one is viable in quantum mechanics but not allowed classically.
Bai, Bing +14 more
core +1 more source
Structure-based discovery of potent and selective melatonin receptor agonists
eLife, 2020 Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel +8 more
doaj +1 more source
The impossibility of non-signaling privacy amplification
, 2009 Barrett, Hardy, and Kent have shown in 2005 that protocols for quantum key agreement exist the security of which can be proven under the assumption that quantum or relativity theory is correct.
Hänggi, Esther +2 more
core +1 more source
Biased Signaling through G Protein-coupled Receptors
YAKUGAKU ZASSHI, 2022 It is well-established that G protein-coupled receptors (GPCRs) transduce signals into cells using G proteins as intermediary molecules. β-Arrestins are molecules involved in regulating GPCRs; however, it has recently been reported that β-arrestins can also mediate signaling through GPCRs.
openaire +2 more sources
Molecules, 2019 G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family.
Metehan Ilter +2 more
doaj +1 more source
Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents [PDF]
, 2011 Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to ...
B. J. Casey +7 more
core +2 more sources
Locational signaling and agglomeration [PDF]
Agglomeration can be caused by asymmetric information and a locational signaling effect: The location choice of workers signals their productivity to potential employers. The cost of a signal is the cost of housing at a location.
Berliant, Marcus, Yu, Chia-Ming
core +4 more sources