Results 31 to 40 of about 230,113 (234)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Toward Mechanistic Design of Surrogate Buffers for Dissolution Testing of pH-Dependent Drug Delivery Systems

Pharmaceutics, 2020
The in vivo dissolution of enteric-coated (EC) products is often overestimated by compendial in vitro dissolution experiments. It is of great interest to mimic the in vivo conditions as closely as possible in vitro in order to predict the in vivo ...
Johannes Andreas Blechar, Jozef Al-Gousous, Christoph Wilhelmy, Annika Marielina Postina, Marcus Getto, Peter Langguth   +5 more
doaj   +1 more source

Fluid Therapy During Cardiopulmonary Resuscitation

Frontiers in Veterinary Science, 2021
Cardiopulmonary arrest (CPA), the acute cessation of blood flow and ventilation, is fatal if left untreated. Cardiopulmonary resuscitation (CPR) is targeted at restoring oxygen delivery to tissues to mitigate ischemic injury and to provide energy ...
Daniel J. Fletcher, Manuel Boller
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Plant electrical signals reveal the joint interactions of bicarbonate- selenium on cadmium transport in Cardamine violifolia

Plant Signaling & Behavior
Cardamine violifolia (C. violifolia), a hyperaccumulator selenium plant species, is a common medicinal and edible species as the primary source of Se supplementation in karst areas.
Juyue Xiao, Antong Xia, Yanyou Wu, Dapeng Wang, Zhanghui Qin, Jiqian Xiang, Gratien Twagirayezu   +6 more
doaj   +1 more source

The effects of a novel bicarbonate loading protocol on serum bicarbonate concentration: a randomized controlled trial

Journal of the International Society of Sports Nutrition, 2019
Background Previous studies have shown that sodium bicarbonate ingestion may enhance intense exercise performance, but may also cause severe gastrointestinal distress.
Adam Marcus, Amerigo Rossi, Andrew Cornwell, Steven A. Hawkins, Nazareth Khodiguian   +4 more
doaj   +1 more source

From Waste to Value: Conversion of Calcium Sulfate to Vaterite via Carbon Capture and Storage

Advanced Functional Materials, EarlyView.
This study introduces a new concept for carbon management that relies on the carbonation of industrial gypsum waste and yields phase‐pure vaterite at ambient conditions without any additives. The obtained vaterite is further shown to be a reactive material that develops compressive strength in aqueous suspensions like conventional cements.
Carlos Pimentel, German Montes‐Hernández, Pablo Almarza‐Cifuentes, Matthias Kellermeier, Alexander E.S. Van Driessche   +4 more
wiley   +1 more source

Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens

Frontiers in Microbiology, 2018
We investigated the effects of bicarbonate on the growth of several different bacteria as well as its effects on biofilm formation and intracellular cAMP concentration in Pseudomonas aeruginosa.
Orsolya Dobay, Krisztina Laub, Balázs Stercz, Adrienn Kéri, Bernadett Balázs, Adrienn Tóthpál, Szilvia Kardos, Pongsiri Jaikumpun, Kasidid Ruksakiet, Paul M. Quinton, Ákos Zsembery   +10 more
doaj   +1 more source