Biginelli reaction catalyzed by copper nanoparticles. [PDF]
PLoS One, 2012 We recently reported a novel synthesis of copper nanoparticles from copper sulphate utilizing the charge-compensatory effect of ionic liquid [bmim]BF(4) and ethylene glycol. The nanoparticles were characterized and found to be stable for one year. Here we hypothesize that the stabilized nanoparticles should be able to catalyze one-pot multicomponent ...
Dewan M +4 more
europepmc +6 more sources
Current progress in asymmetric Biginelli reaction: an update [PDF]
Molecular Diversity, 2018 The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones and related heterocyclic compounds. In the past decades, the asymmetric variants of this reaction have been at the
Majid M. Heravı +3 more
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Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]
ChemSusChemKnoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM +3 more
europepmc +2 more sources
New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]
Chem Biol Drug DesWe report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C +4 more
europepmc +2 more sources
High-Shear Enhancement of Biginelli Reactions in Macromolecular Viscous Media. [PDF]
Macromol Rapid CommunBiginelli reactions are important multicomponent reactions in macromolecular chemistry. it is demonstrated that by using the vortex fluidic device (VFD) Biginelli reactions can be completed at room temperature in just 1 h. However, the critical need to understand solution viscosity as a function of macromolecular chain length to better understand ...
Bui AH +5 more
europepmc +2 more sources
A Brønsted acidic ionic liquid anchored to magnetite nanoparticles as a novel recoverable heterogeneous catalyst for the Biginelli reaction. [PDF]
RSC Adv, 2021 Oboudatian HS, Naeimi H, Moradian M.
europepmc +3 more sources
A four-component modified Biginelli reaction: A novel approach for C-2 functionalized dihydropyrimidines. [PDF]
Turk J Chem, 2021 Narkhede H, Dhake A, Balasubramaniyan V.
europepmc +3 more sources
Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies. [PDF]
Arch Pharm (Weinheim)Biginelli dihydropyrimidines (DHPM) were designed and synthesized (GD1–GD14), and their binding mechanism to L‐(Cav1.2)/T‐(Cav3.2) type calcium channels was illuminated by advanced molecular modeling techniques. Abstract Biginelli dihydropyrimidines (DHPMs) are considered superior over 1,4‐dihydropyridines (DHPs) in terms of both light and metabolic ...
Gündüz MG +8 more
europepmc +2 more sources
An Improved Protocol for Biginelli Reaction
Green and Sustainable Chemistry, 2013 [Hmim][Tfa] was used as catalyst for the Biginelli reaction under microwave heating. Low catalyst loading, reduced reaction time and operational simplicity are the main highlights of this protocol. The proposed protocol was found active in the synthesis of 30 different biologically active compounds.
Vivek Srivastava
openalex +3 more sources
Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength. [PDF]
RSC Adv, 2019 Freitas EF +5 more
europepmc +3 more sources