Results 21 to 30 of about 4,540 (259)

Highly Enantioselective Organocatalytic Biginelli Reaction [PDF]

Journal of the American Chemical Society, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiao-Hua, Chen, Xiao-Ying, Xu, Hua, Liu, Lin-Feng, Cun, Liu-Zhu, Gong   +4 more
openaire   +2 more sources

Double catalytic effect of (PhNH3)2CuCl4 in a novel, highly efficient synthesis of 2-oxo and thioxo-1,2,3,4-tetra-hydopyrimidines [PDF]

Journal of the Serbian Chemical Society, 2015
An innovative route for the construction of 2-oxo and thioxo-1,2,3,4-tetrahydropyrimidines was delineated through a multicomponent reaction under Biginelli conditions, starting from different aromatic aldehydes, β-ketoesters and urea or thiourea.
Janković Nenad, Bugarčić Zorica, Marković Svetlana   +2 more
doaj   +1 more source

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions

Pharmaceuticals, 2022
The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Francisco Sánchez-Sancho, Marcos Escolano, Daniel Gaviña, Aurelio G. Csáky, María Sánchez-Roselló, Santiago Díaz-Oltra, Carlos del Pozo   +6 more
doaj   +1 more source

Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics [PDF]

, 2015
The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1.
Ajani, Olayinka O., Akinsiku, A.A., Isaac, Jessica T., Owoeye, Taiwo F.   +3 more
core   +4 more sources

New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]

Chem Biol Drug Des
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C, Elstow TZ, Brancale A, Clarkson RWE, Westwell AD.   +4 more
europepmc   +2 more sources

Synthesis, Characterization, and DFT Calculation of some New Pyrimidine Derivatives and Theoretical Studies on the Corrosion Inhibition Performance [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2022
In this study, 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) - 1,2,3,4-tetrahydroxypyrimidine (1); 5-benzoyl-6-phenyl-4- (4- (trifluoromethoxy) phenyl) -1,2,3,4-tetrahydrothioxypyrimidine (2) and 5-benzoyl-6-phenyl-4- (3,5-dimethoxy) phenyl) -1,2 ...
Esvet Akbas, Adem Ruzgar, Akbas Cagla, Sahin Ertan   +3 more
doaj   +1 more source

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones

Molecules, 2009
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described.
Ji-De Wang, Chen-Jiang Liu
doaj   +1 more source

One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Molecules, 2020
A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea.
Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga   +8 more
doaj   +1 more source

High-Shear Enhancement of Biginelli Reactions in Macromolecular Viscous Media. [PDF]

Macromol Rapid Commun
Biginelli reactions are important multicomponent reactions in macromolecular chemistry. it is demonstrated that by using the vortex fluidic device (VFD) Biginelli reactions can be completed at room temperature in just 1 h. However, the critical need to understand solution viscosity as a function of macromolecular chain length to better understand ...
Bui AH, Rowlands NB, Fernando Pulle AD, Gibbs Medina SA, Rohrsheim TJ, Tuten BT.   +5 more
europepmc   +2 more sources