Results 31 to 40 of about 4,540 (259)

An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

Molecules, 2015
We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions.
Yonghong Zhang, Bin Wang, Xiaomei Zhang, Jianbin Huang, Chenjiang Liu   +4 more
doaj   +1 more source

A Brønsted acid catalysed enantioselective Biginelli reaction [PDF]

Green Chemistry, 2017
A chiral derivative of 1,2-benzenedisulfonimide, namely (−)-4,5-dimethyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide is herein proven to be an efficient chiral catalyst in a one pot three-component Biginelli reaction.
BARBERO, Margherita, CADAMURO, Silvano, DUGHERA, Stefano   +2 more
openaire   +1 more source

N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis [PDF]

, 2016
Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list ...
Farmer, Thomas James, Hunt, Andrew John, Moonen, Kristof, Parker, Helen Louise, Sherwood, James Richard   +4 more
core   +1 more source

Clean 3,4-Dihydropyrimidones Synthesis via Biginelli Reaction over Supported Molybdenum: Structural and Textural Characteristic of αMoO3

Bulletin of Chemical Reaction Engineering & Catalysis, 2020
A one-pot three-component synthesis of dihydropyrimidinones (DHPMs) via Biginelli reaction was carried out at 100 °C using benzaldehyde, ethyl acetoacetate and urea as reactants, in the presence of ethanol and free solvent, in heterogeneous catalytic ...
Ouzna Kheffache, Cristina Lopez-Olmos, Inmaculada Rodriguez-Ramos, Ouiza Cherifi   +3 more
doaj   +1 more source

Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2018
The Biginelli reaction is a highly versatile reaction that leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets.
Itamar Luís Gonçalves, Luciano Porto Kagami, Gustavo Machado das Neves, Liliana Rockenbach, Leonardo Davi, Alceu Felipe Soares, Solange Cristina Garcia, Vera Lucia Eifler-Lima   +7 more
doaj   +1 more source

Lithium-Acetate-Mediated Biginelli One-Pot Multicomponent Synthesis under Solvent-Free Conditions and Cytotoxic Activity against the Human Lung Cancer Cell Line A549 and Breast Cancer Cell Line MCF7

The Scientific World Journal, 2012
Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent-free, and eco-friendly conditions in a one-pot reaction of 1,3-dicarbonyl compounds, aldehydes, and urea/thiourea/acetyl thiourea ...
Harshita Sachdeva, Diksha Dwivedi
doaj   +1 more source

A mini-review on Biginelli adducts with notable pharmacological properties

Journal of Advanced Research, 2015
Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities.
Ângelo de Fátima, Taniris C. Braga, Leonardo da S. Neto, Bruna S. Terra, Breno G.F. Oliveira, Daniel L. da Silva, Luzia V. Modolo   +6 more
doaj   +1 more source

Aqueous solution of biogenic carboxylic acids as sustainable catalysts and green reaction media for the high-yielding synthesis of Biginelli adducts, Hantzsch esters, and substituted pyridines. [PDF]

RSC Adv
Prabhakar PS, Sahoo J, Alnaser IA, Seikh AH, Karim MR, Dutta S.   +5 more
europepmc   +2 more sources

Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies. [PDF]

Arch Pharm (Weinheim)
Biginelli dihydropyrimidines (DHPM) were designed and synthesized (GD1–GD14), and their binding mechanism to L‐(Cav1.2)/T‐(Cav3.2) type calcium channels was illuminated by advanced molecular modeling techniques. Abstract Biginelli dihydropyrimidines (DHPMs) are considered superior over 1,4‐dihydropyridines (DHPs) in terms of both light and metabolic ...
Gündüz MG, Dengiz C, Denzinger K, Huang S, Lee JT, Nafie JW, Armstrong DW, Wolber G, Zamponi GW.   +8 more
europepmc   +2 more sources

One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives

Results in Chemistry, 2022
An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
doaj   +1 more source