Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis [PDF]
Nature CommunicationsESKAPE pathogens-induced meningitis seriously threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB).
Weinan Jiang +12 more
doaj +2 more sources
A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC [PDF]
Cancer Biology & MedicineObjective: Osimertinib (OSI) therapy, a cornerstone in treating non-small cell lung cancer (NSCLC), has been severely limited by rapidly developing acquired resistance.
Mei Peng +9 more
doaj +2 more sources
Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes. [PDF]
PLoS ONEBackgroundSodium-glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data comparing them with metformin, the canonical biguanide, remain sparse in Japan ...
Eiji Nakatani +15 more
doaj +2 more sources
Effects of Biguanide-PROTACs in Pancreatic Cancer Cells [PDF]
MoleculesThis study focuses on the synthesis of Biguanide-PROTACs, formed by conjugating the biguanide motif with a spacer and a ligand for recognition subunits of two E3 ubiquitin ligases.
Julie Vatté +3 more
doaj +2 more sources
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity [PDF]
Journal of Medicinal Chemistry, 2018 We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and X-ray ...
Feng Chen +2 more
exaly +4 more sources
Pesquisa Agropecuária Tropical, 2007 <!-- @page { margin: 2cm } P { margin-bottom: 0.21cm } --> <p class="western" style="font-style: normal;" align="JUSTIFY">The aim of the present work was to evaluate the effect of treated water with polymeric biguanide (Vantocil IB), with ...
Dirson Vieira +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2018 The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri +13 more
doaj +2 more sources
Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]
PharmaceuticalsN-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin +2 more
doaj +2 more sources
Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]
Contact Dermatitis, 2020 AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Thanisorn Sukakul +9 more
openaire +4 more sources
From Bench to Application: Evaluating the In Vitro and In Vivo Efficacy of a Polyhexamethylene Biguanide and Cross-Linked Hyaluronic Acid-Based Antiseptic Solution. [PDF]
J Clin MedD'Oria F +5 more
europepmc +3 more sources