Results 21 to 30 of about 27,566 (317)

The uses of biguanides in diabetes mellitus [PDF]

Postgraduate Medical Journal, 1968
H. Keen, R. J. Jarrett
openalex   +4 more sources

Polyhexamethylene biguanide and its antimicrobial role in wound healing: a narrative review.

Journal of Wound Care, 2023
A wound offers an ideal environment for the growth and proliferation of a variety of microorganisms which, in some cases, may lead to localised or even systemic infections that can be catastrophic for the patient; the development of biofilms exacerbates ...
M. Rippon, A. Rogers, K. Ousey
semanticscholar   +1 more source

Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

Molecules, 2021
Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu, Yufang Cao, Yu Luo, Di Xiao, Wei Wang, Zhiren Wang, Xiaoping Yang   +6 more
doaj   +1 more source

Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System

BMC Medical Informatics and Decision Making, 2023
Background Biguanides and sulfonylurea are two classes of anti-diabetic medications that have commonly been prescribed all around the world. Diagnosis of biguanide and sulfonylurea exposures is based on history taking and physical examination; thus ...
O. Mehrpour, Farhad Saeedi, S. Nakhaee, Farbod Tavakkoli Khomeini, A. Hadianfar, Alireza Amirabadizadeh, C. Hoyte   +6 more
semanticscholar   +1 more source

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

Journal of experimental & clinical cancer research : CR, 2022
Background Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical ...
F. Barbieri, A. Bosio, A. Pattarozzi, M. Tonelli, A. Bajetto, I. Verduci, F. Cianci, G. Cannavale, L. Palloni, Valeria Francesconi, S. Thellung, P. Fiaschi, S. Mazzetti, S. Schenone, B. Balboni, S. Girotto, P. Malatesta, A. Daga, G. Zona, M. Mazzanti, T. Florio   +20 more
semanticscholar   +1 more source

Biguanide- and Oligo(Ethylene Glycol)-Functionalized Poly(3,4-Ethylenedioxythiophene): Electroactive, Antimicrobial, and Antifouling Surface Coatings

Frontiers in Chemistry, 2022
The challenge of infectious diseases remains a critical concern to the global public health. Recently, it is common to encounter touch-screen electronic devices everywhere to access services.
Hailemichael Ayalew, Syed Atif Ali, Syed Atif Ali, Syed Atif Ali, Jia-Wei She, Hsiao-hua Yu, Hsiao-hua Yu   +6 more
doaj   +1 more source

First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors

Investigational new drugs, 2022
Preclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS).
F. Janku, S. Beom, Y. Moon, Tae won Kim, Young G. Shin, D. Yim, G. Kim, H. Kim, Sun Young Kim, J. Cheong, Young Woo Lee, B. Geiger, S. Yoo, A. Thurston, D. Welsch, M. Rudoltz, S. Rha   +16 more
semanticscholar   +1 more source

Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides

SynOpen, 2021
This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi, Marie Fabre, Cyril Ronco, Rachid Benhida   +3 more
doaj   +1 more source

Dual Crosslinked Ion-Based Bacterial Cellulose Composite Hydrogel Containing Polyhexamethylene Biguanide

Membranes, 2022
Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB)
Baramee Chanabodeechalermrung, Tanpong Chaiwarit, S. Sommano, P. Rachtanapun, Nutthapong Kantrong, Chuda Chittasupho, Pensak Jantrawut   +6 more
semanticscholar   +1 more source

Synthesis of antibacterial polyether biguanide curing agent and its cured antibacterial epoxy resin

Designed Monomers and Polymers, 2021
At present, bacteria continue to threaten human health, and the resistance of bacteria to antibiotics continues to increase, so the development of new antibacterial agents and antibacterial materials is increasingly important to ensure human health.
Rui Li, Guoxing Yang, Yudan Wang, Lijia Liu, Qiang Wang, Guan Wang, Xiao Ouyang   +6 more
doaj   +1 more source