Results 31 to 40 of about 19,462 (277)

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB) [PDF]

, 2015
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
A Ponte-Sucre, AA Momeni, AF Jebran, AM Carmona-Ribeiro, B Castillo, B Monge-Maillo, Bianca Röger, BLF Schamber-Reis, CM Choi, D Gerit, D Lockwood, DP Eiras, DS Lima-Junior, E Moreno, E Von Stebut, FB Chekeni, G Bringmann, G Carneiro, G Carneiro, G Morizot, G Müller, G Rusciano, G Walls, H Yin, Heidrun Moll, I Arevalo, IJ Gonzalez-Leal, J Alvar, JR Ramírez-Pineda, K Kaehn, Kantaraja Chindera, KT Andrews, L Novo, L-I McCall, Liam Good, Lorenz Meinel, LP O’Malley, M Ghosh, M Yamamoto, M-A Hartley, Maria Cecilia Amstalden, Martina Schultheis, Mary Ann McDowell, MJ Allen, MN Jabbour, MS Bailey, N Datta, Nina Hecht, Nor Fadhilah Kamaruzzaman, R Firdessa, R Hurdayal, Rebuma Firdessa, S Das, S Gupta, S Sundar, S Wessels, Salah A Ben, SK Samal, T Hirsch, T Ikeda, T Lang, T Sato, Tessa Lühmann, Tobias A. Oelschlaeger   +63 more
core   +3 more sources

Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study

Acta Pharmaceutica, 2018
Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media ...
Bardaweel Sanaa K., Alsalamat Husam A., Aleidi Shereen M., Bashatwah Rasha M.   +3 more
doaj   +1 more source

Efficacy of 0.2% povidone-iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures. [PDF]

Vet Ophthalmol
Abstract Objective This retrospective study evaluates the efficacy of povidone‐iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Animals Studied Horses that underwent routine ophthalmic surgery and procedures.
Farkas A, Thieme K, Soimala T, Jensen CK, Eule JC.   +4 more
europepmc   +2 more sources

Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

Molecules, 2021
Bacterial strains become resistant to almost all classes of antibiotics, which makes it necessary to look for new substitutes. The non-absorbable ciprofloxacin–biguanide bismuth complex, used locally, may be a good alternative to a conventional therapy ...
Dorota Kowalczuk, Agata Gładysz, Monika Pitucha, Daniel M. Kamiński, Agnieszka Barańska, Bartłomiej Drop   +5 more
doaj   +1 more source

Bacterial Growth Kinetics under a Novel Flexible Methacrylate Dressing Serving as a Drug Delivery Vehicle for Antiseptics [PDF]

, 2013
A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics.
Archibald, Assadian, Axel Kramer, Beldon, Braga, Chen, Christina Forstner, Clark, Cutting, David Leaper, Deitch, Disemond, Eberlein, Fang, Fitzgerald, Henry-Stanley, Hirsch, Johannes Leitgeb, Keith Cutting, Kim, Lalani, Leaper, Leaper, Migliaresi, Minnich, Nathan, Nordmann, Ojan Assadian, Rupert Schuster, Sibbald, Tsou, Vanscheidt, Verena Dosch, Wang, Winter   +34 more
core   +4 more sources

Ueber Biguanid [PDF]

Berichte der deutschen chemischen Gesellschaft, 1879
n ...
openaire   +2 more sources

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]

, 2016
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic
Agip, Ahmed-Noor A, Bridges, Hannah R, Hirst, Judy, Sirviö, Ville A   +3 more
core   +1 more source

Antitumor Effects and Mechanisms of Metabolic Syndrome Medications on Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2022
Kyoko Oura, Asahiro Morishita, Joji Tani, Tsutomu Masaki Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, JapanCorrespondence: Kyoko Oura, Department of Gastroenterology and Neurology, Kagawa University, 1750 ...
Oura K, Morishita A, Tani J, Masaki T
doaj  

Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]

, 2015
Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C, Casarin, A, Indraccolo, Stefano, Nardin, M, Nicoletto, Mo, Pomerri, Fabio, Randon, G, Zulato, E   +7 more
core   +1 more source

Prophylaxis of Ocular Infection in the Setting of Intraocular Surgery: Implications for Clinical Practice and Risk Management

Ophthalmology and Therapy, 2023
In this review we discuss the role of intraocular surgery preoperative prophylaxis. The correct choice of antimicrobial drug is variable in each surgical setting, according to the available strengths of evidence, the anatomical district involved, and the
Alfredo Borgia, Daniela Mazzuca, Marcello Della Corte, Nicola Gratteri, Giovanni Fossati, Raffaele Raimondi, Luca Pagano, Vincenzo Scorcia, Giuseppe Giannaccare   +8 more
doaj   +1 more source