Results 31 to 40 of about 17,950 (199)

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Mechanism of Hydrogen Sulfide Generation and Prevention Strategies in Oil and Gas Fields: A Case Study of the Sickle Bay Operation Area

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT To address the persistent exceedance of hydrogen sulfide (H2S) concentrations and the limited effectiveness of existing treatments in the Sickle Bay oil production area, this study deeply analyzes the mechanism of H2S generation in the Sickle Bay oil production area and proposes targeted prevention and control strategies. The results show that
Bo Lei, Yao‐long Li, Bao‐ping Bai, Xiang‐de Zhang, Guan‐tao Shi, Yong‐long Xie, Chen‐xiao Hou, Cong‐Yu Ke   +7 more
wiley   +1 more source

Poly(hexamethylene biguanide) salicylate as a novel ionic liquid with antibacterial properties in the production of poly(vinyl alcohol) films

Materials Research Express, 2022
The presented work describes the effect of poly(hexamethylene biguanide) salicylate (PHMB-SA) ionic liquid on the properties of poly(vinyl alcohol) film. The ionic liquid synthetized is used as an antimicrobial agent. The ionic liquid consist of the poly(
Anna Słubik, Iwona Masłowska-Lipowicz, Dorota Wieczorek, Łucja Wyrębska   +3 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Successful Use of Locally Applied Polyhexamethylene Biguanide as an Adjunct to the Treatment Of Fungal Osteomyelitis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2013
Fungal osteomyelitis is rare in immunocompetent patients and is often difficult to cure, even with optimal medical and surgical management. The authors present two cases of fungal osteomyelitis in which the common swimming pool cleaner, polyhexamethylene
Genevieve Walls, Lisa Noonan, Elizabeth Wilson, David Holland, Simon Briggs   +4 more
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Real‐World Weight Loss Is Associated With a Reduction in Cancer Risk

Obesity, EarlyView.
ABSTRACT Objective Obesity is a major risk factor for multiple cancers, yet the impact of nonsurgical weight loss on cancer risk remains uncertain. Our objective was to evaluate whether real‐world nonsurgical weight loss is associated with a reduced risk of developing cancer.
Kenda Alkwatli, Huijun Xiao, Arshiya Mariam‐Smith, Nerea Lopetegui, Marcio L. Griebeler, Bartolome Burguera, Kevin M. Pantalone, Daniel M. Rotroff   +7 more
wiley   +1 more source

The Activity of PHMB and Other Guanidino Containing Compounds against Acanthamoeba and Other Ocular Pathogens

Microorganisms, 2022
In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG),
Dharanga Ratnayake, Michael Ansah, Enas Al Ani, Wayne Heaselgrave   +3 more
doaj   +1 more source

Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing—A Market Survey in Four European Countries

Contact Dermatitis, EarlyView.
Most solid shampoos (68.6%) did not contain preservatives according to Annex V of the EU Cosmetics Regulation (EC 1223/2009), while all liquid shampoos did. The number of preservatives used was significantly greater in liquid shampoos. ABSTRACT Background Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions ...
Wolfgang Uter, Anders B. Funch, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Ying X. Teo, Jeanne D. Johansen, Carola Lidén, Ian R. White   +7 more
wiley   +1 more source