Results 31 to 40 of about 27,566 (317)

Synthesis, Characterization and Structural Analysis of Two New Biguanide Complexes

Crystals, 2023
This study reports on the synthesis and characterization of two new coordination compounds of the active pharmaceutical ingredient metformin and transition metals.
Andrea Pastrana-Dávila, Gianella Minotta, Javier Ellena, Pedro H. O. Santiago, Richard F. D’Vries   +4 more
doaj   +1 more source

Polyhexamethylene biguanide promotes adaptive cross-resistance to gentamicin in Escherichia coli biofilms

Frontiers in Cellular and Infection Microbiology, 2023
Antimicrobial resistance is a critical public health issue that requires a thorough understanding of the factors that influence the selection and spread of antibiotic-resistant bacteria.
Raphaël Charron, Raphaël Charron, Pierre Lemée, Antoine Huguet, Ornella Minlong, Marine Boulanger, Paméla Houée, Christophe Soumet, Romain Briandet, Arnaud Bridier   +9 more
doaj   +1 more source

Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis

Internal medicine, 2022
Biguanide is an ideal drug for the treatment of type 2 diabetes mellitus. When used appropriately, the incidence of lactic acidosis is reported to be very low. Risk factors associated with biguanide-related lactic acidosis include chronic kidney disease,
H. Tamaki, Hideo Tsushima, N. Kachi, Fumie Jimura   +3 more
semanticscholar   +1 more source

Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions

International Journal of Molecular Sciences, 2022
Biguanides, particularly the widely prescribed drug metformin, have been marketed for many decades and have well-established absorption profiles. They are commonly administered via the oral route and, despite variation in oral uptake, remain commonly ...
Melissa A Jones, C. Ionescu, Daniel Walker, S. Wagle, B. Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, J. Kuthubutheen, Daniel Brown, M. Atlas, M. Mikov, A. Mooranian, H. Al‐Salami   +13 more
semanticscholar   +1 more source

Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models

Cells, 2023
The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee, ChuHee Lee, Hae-Min Moon, Se-Young Jo, Se Jin Jang, Young-Ah Suh   +5 more
doaj   +1 more source

Effect of Polyhexamethylene Biguanide in Combination with Undecylenamidopropyl Betaine or PslG on Biofilm Clearance

International Journal of Molecular Sciences, 2021
Hospital-acquired infection is a great challenge for clinical treatment due to pathogens’ biofilm formation and their antibiotic resistance. Here, we investigate the effect of antiseptic agent polyhexamethylene biguanide (PHMB) and undecylenamidopropyl ...
Yaqiang Zheng, Di Wang, Luyan Z. Ma
semanticscholar   +1 more source

The Effect of Metformin as an Adjunct Therapy in Adolescents with Type 1 Diabetes [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The strict control of blood glucose levels in adolescents with Type 1 Diabetes Mellitus (T1DM) is accompanied with a considerable long term decrease in microvasular and macrovascular complications.
Aria Setoodeh, Abdollah Didban, Ali Rabbani, Azadeh Sayarifard, Farzaneh Abbasi, Fatemeh Sayarifard, Fatemeh Hoseinzade   +6 more
doaj   +1 more source

Comparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic review [PDF]

, 2014
The prevalence of diabetes mellitus is rising globally, and it induces a substantial public health burden to the healthcare systems. Its optimal control is one of the most significant challenges faced by physicians and policy-makers.
A Juutilainen, AA Riedel, AI Adler, AJ Garber, AR Saltiel, BD Green, BI Yan, BM Scirica, Brian C. Y. Fong, C Castell, C Levetan, Carmen K. M. Fan, CC Cowie, CE Van Dijk, CJ Bailey, CN Chan, Daisy D. X. Zhang, DC Simonson, DR Owens, DS Schade, FA Guisasola, François Blachier, Harry H. X. Wang, J Lopatynski, J Mest H, J Rosenstock, K Kaku, Kirin Q. L. Liu, L Groop, M Kobayashi, M Stumvoll, M Takihata, Mandy W. M. Kwan, Martin C. S. Wong, MC Wong, N Inagaki, N Inagaki, O Mosenzon, R Kawamori, RA DeFronzo, S Aronoff, S Clement, SE Kahn, SE Kahn, SE Nissen, Shannon T. S. Li, Sian M. Griffiths, Sky W. M. Chan, SL Zhang, T Kadowaki, V Mohan, W Gareth, W Yang, WB White, Y Guan, Y Seino, Y Seino, YG Kim, Z Zeng   +58 more
core   +6 more sources

Mono- and Dinuclear Aluminium Complexes Derived from Biguanide and Carbothiamide Ligands

Inorganics, 2021
Dianionic N,N-chelating ligands play a crucial role in coordination chemistry, but reports on related complexes remain limited to certain types of ligands.
Maximilian Dehmel, Helmar Görls, Robert Kretschmer   +2 more
doaj   +1 more source

Insights into the Polyhexamethylene Biguanide (PHMB) Mechanism of Action on Bacterial Membrane and DNA: A Molecular Dynamics Study

bioRxiv, 2020
Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due the ability of PHMB to perforate the bacterial phospholipid membrane leading ...
S. Sowlati-Hashjin, P. Carbone, M. Karttunen   +2 more
semanticscholar   +1 more source