Results 41 to 50 of about 28,403 (287)

Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial. [PDF]

Hematol Oncol
ABSTRACT Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by the activation of the JAK‐STAT pathway. Previous evidence showed that metformin might be a possible therapeutic option for treating JAK2‐mediated myeloproliferative neoplasms.
Melo Campos P, Pagnano KBB, Niemann FS, Mancuso RI, Della Via FI, Congrains A, Coelho-Silva JL, Tinoco ÂC, Assis-Mendonça GR, Freitas LLL, Traina F, Saad STO.   +11 more
europepmc   +2 more sources

Early drug use of dapagliflozin prescribed by general practitioners and diabetologists in Germany. [PDF]

, 2016
OBJECTIVES: Dapagliflozin is an inhibitor of the human sodium-glucose co-transporter 2 (SGLT2) that has been shown to improve glycaemic control in patients with type 2 diabetes mellitus (T2DM).
Hammar, Niklas, Hankins, Matthew, Kim, Joseph, Tsai, Katherine   +3 more
core   +1 more source

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB) [PDF]

, 2015
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
A Ponte-Sucre, AA Momeni, AF Jebran, AM Carmona-Ribeiro, B Castillo, B Monge-Maillo, Bianca Röger, BLF Schamber-Reis, CM Choi, D Gerit, D Lockwood, DP Eiras, DS Lima-Junior, E Moreno, E Von Stebut, FB Chekeni, G Bringmann, G Carneiro, G Carneiro, G Morizot, G Müller, G Rusciano, G Walls, H Yin, Heidrun Moll, I Arevalo, IJ Gonzalez-Leal, J Alvar, JR Ramírez-Pineda, K Kaehn, Kantaraja Chindera, KT Andrews, L Novo, L-I McCall, Liam Good, Lorenz Meinel, LP O’Malley, M Ghosh, M Yamamoto, M-A Hartley, Maria Cecilia Amstalden, Martina Schultheis, Mary Ann McDowell, MJ Allen, MN Jabbour, MS Bailey, N Datta, Nina Hecht, Nor Fadhilah Kamaruzzaman, R Firdessa, R Hurdayal, Rebuma Firdessa, S Das, S Gupta, S Sundar, S Wessels, Salah A Ben, SK Samal, T Hirsch, T Ikeda, T Lang, T Sato, Tessa Lühmann, Tobias A. Oelschlaeger   +63 more
core   +4 more sources

Synthesis and Activity of Biomimetic Biofilm Disruptors [PDF]

, 2013
Biofilms are often associated with human bacterial infections, and the natural tolerance of biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could become useful adjuncts to antibiotic therapy.
Böttcher, Thomas, Clardy, Jon C., Kolodkin-Gal, Ilana, Kolter, Roberto Guillermo, Losick, Richard M.   +4 more
core   +1 more source

Antitumor Effects and Mechanisms of Metabolic Syndrome Medications on Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2022
Kyoko Oura, Asahiro Morishita, Joji Tani, Tsutomu Masaki Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, JapanCorrespondence: Kyoko Oura, Department of Gastroenterology and Neurology, Kagawa University, 1750 ...
Oura K, Morishita A, Tani J, Masaki T
doaj  

Biguanide-, imine-, and guanidine-based networks as catalysts for transesterification of vegetable oil [PDF]

, 2010
Polycationic systems based on poly(hexamethylene biguanide) (PHMBG), branched polyethyleneimine (PEI) and poly(N-vinylguanidine) (PVG) have been evaluated as heterogeneous catalysts for the transesterification of sunflower oil by methanol.
Alvarez, Michael, Barletta, Gabriel L., Bromberg, Lev E., Fasoli, Ezio, Hatton, T. Alan   +4 more
core   +1 more source

Does microbicide use in consumer products promote antimicrobial resistance? A critical review and recommendations for a cohesive approach to risk assessment [PDF]

, 2013
The increasing use of microbicides in consumer products is raising concerns related to enhanced microbicide resistance in bacteria and potential cross resistance to antibiotics.
Bloomfield, Sally, Coelho, Joana Rosado, Collier, Phillip J., Cookson, Barry, Fanning, Séamus, Hartemann, Philippe, Hill, Andrew, Maillard, Jean-Yves, Mcbain, Andrew J., Oggioni, Marco, Sattar, Syed, Schweizer, Herbert P., Threlfall, John   +12 more
core   +3 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Prophylaxis of Ocular Infection in the Setting of Intraocular Surgery: Implications for Clinical Practice and Risk Management

Ophthalmology and Therapy, 2023
In this review we discuss the role of intraocular surgery preoperative prophylaxis. The correct choice of antimicrobial drug is variable in each surgical setting, according to the available strengths of evidence, the anatomical district involved, and the
Alfredo Borgia, Daniela Mazzuca, Marcello Della Corte, Nicola Gratteri, Giovanni Fossati, Raffaele Raimondi, Luca Pagano, Vincenzo Scorcia, Giuseppe Giannaccare   +8 more
doaj   +1 more source