Results 61 to 70 of about 19,462 (277)

Management of type II Diabetes Mellitus [PDF]

, 2002
There is currently no cure for diabetes mellitus (DM). Irrespective of whether type I or type II diabetes is treated, the overall goals of management and therapy are targeted towards patient well being and may be summarised as follows.peer ...
Tonna, Antonella
core  

Synthesis and Activity of Biomimetic Biofilm Disruptors [PDF]

, 2013
Biofilms are often associated with human bacterial infections, and the natural tolerance of biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could become useful adjuncts to antibiotic therapy.
Böttcher, Thomas, Clardy, Jon C., Kolodkin-Gal, Ilana, Kolter, Roberto Guillermo, Losick, Richard M.   +4 more
core   +1 more source

Finerenone, glycaemic status, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

European Journal of Heart Failure, EarlyView.
Finerenone and glycaemic status in patients with heart failure with mildly reduced/preserved ejection fraction. CI, confidence interval; CV, cardiovascular; HF, heart failure; HR, hazard ratio; RR, rate ratio. Abstract Aims The efficacy and safety of the non‐steroidal mineralocorticoid receptor antagonist, finerenone, have not been examined in patients
Jawad H. Butt, Pardeep S. Jhund, Alasdair D. Henderson, Brian L. Claggett, Akshay S. Desai, Carolyn S.P. Lam, Meike Brinker, Patrick Schloemer, Prabhakar Viswanathan, Andrea Lage, Katja Rohwedder, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J.V. McMurray   +18 more
wiley   +1 more source

ANTIBACTERIAL ACTIVITY AND QUANTIFICATION OF POLYHEXAMETHTYLENE BIGUANIDE HYDROCHLORIDE IN MUSCULAR TISSUES AND VISCERA OF BROILERS ATIVIDADE ANTIBACTERIANA E QUANTIFICAÇÃO DE CLORIDRATO DE POLIHEXAMETILENO BIGUANIDA (P.H.M.B.) EM TECIDOS MUSCULARES E VÍCERAS DE FRANGOS

Pesquisa Agropecuária Tropical, 2007
<!-- @page { margin: 2cm } --> <p class="western" align="justify">Trials were carried out in order to check the viability of polyhexamethylene biguanide hydrochloride in the control of pathogenic and degenerating bacteria in carcass of ...
Albenones José de Mesquita, Moacir Evandro Lage, Guilherme Roberto de Oliveira, Cristiano Sales Prado   +3 more
doaj   +1 more source

New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes [PDF]

, 2015
Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and
Díaz Andrade, Angélica María, Katsarava, Ramaz, Puiggalí Bellalta, Jordi, Tugushi, David, Valle Mendoza, Luis Javier del   +4 more
core   +2 more sources

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Determination of polyhexamethylene biguanide hydrochloride

Reviews in Analytical Chemistry, 2014
Polyhexamethylene biguanide hydrochloride (PHMB-HCl) is widely used as a disinfectant in personal care products such as cosmetics and toiletries and as a sanitizer in swimming pools. PHMB-HCl possesses marked characteristics of cationic polyelectrolytes.
Masadome Takashi, Hattori Toshiaki
doaj   +1 more source

Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis

Case Reports in Ophthalmology, 2011
Aims: To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment.
Giulio Ferrari, Stanislav Matuska, Paolo Rama   +2 more
doaj   +1 more source

Biguanides in combination with olaparib limits tumorigenesis of drug‐resistant ovarian cancer cells through inhibition of Snail

Cancer Medicine, 2020
Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival.
Qiong Wang, Vanessa M. López‐Ozuna, Tahira Baloch, Joanne Bithras, Oreekha Amin, Roy Kessous, Liron Kogan, Ido Laskov, Amber Yasmeen   +8 more
doaj   +1 more source

Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?

Biomolecules, 2021
Several studies reported that metformin, the most widely used drug for type 2 diabetes, might affect cancer aggressiveness. The biguanide seems to directly impair cancer energy asset, with the consequent phosphorylation of AMP-activated protein kinase ...
Cecilia Marini, Vanessa Cossu, Matteo Bauckneht, Francesco Lanfranchi, Stefano Raffa, Anna Maria Orengo, Silvia Ravera, Silvia Bruno, Gianmario Sambuceti   +8 more
doaj   +1 more source