Results 1 to 10 of about 354,033 (333)

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

Frontiers in Medicine, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Vik Meadows, Vik Meadows, Lindsey Kennedy, Debjyoti Kundu, Gianfranco Alpini, Gianfranco Alpini, Heather Francis, Heather Francis   +7 more
doaj   +3 more sources

Bile Acid Detection Techniques and Bile Acid-Related Diseases

Frontiers in Physiology, 2022
Bile acid is a derivative of cholinergic acid (steroidal parent nucleus) that plays an important role in digestion, absorption, and metabolism. In recent years, bile acids have been identified as signaling molecules that regulate self-metabolism, lipid ...
Xiang Zhao, Zitian Liu, Fuyun Sun, Lunjin Yao, Guangwei Yang, Kexin Wang   +5 more
doaj   +3 more sources

Systematic identification of secondary bile acid production genes in global microbiome [PDF]

mSystems
Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes ...
Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao   +11 more
doaj   +2 more sources

Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes

Hepatology Communications, 2021
Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [SLCO1B1]) and OATP1B3 (SLCO1B3) serve as transporters for hepatic uptake of important endogenous substances and several commonly ...
Akihiko Kimura, Tatehiro Kagawa, Hajime Takei, Yoshihiro Maruo, Hiroshi Sakugawa, Takahiro Sasaki, Tsuyoshi Murai, Nakayuki Naritaka, Hajime Takikawa, Hiroshi Nittono   +9 more
doaj   +1 more source

Profiling of Urinary Glucuronidated Bile Acids across Age Groups

Metabolites, 2022
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, Hiroshi Nittono   +6 more
doaj   +1 more source

Dietary Bile Acid Supplementation Could Regulate the Glucose, Lipid Metabolism, and Microbiota of Common Carp (Cyprinus carpio L.) Fed with a High-Lipid Diet

Aquaculture Nutrition, 2023
This study sought to examine the role of bile acids in the regulation of glucose and lipid metabolism, intestinal flora, and growth in high-fat diet-fed common carp (Cyprinus carpio L.). Fish (6.34±0.07 g) were fed for 56 days with three different diets,
Liping Yang, Mingyu Liu, Mengjuan Zhao, Shaoyang Zhi, Wenlei Zhang, Leya Qu, Jinrui Xiong, Xiao Yan, Chaobin Qin, Guoxing Nie, Shengpeng Wang   +10 more
doaj   +1 more source

Berberine alters gut microbial function through modulation of bile acids

BMC Microbiology, 2021
Background Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient lipid profiles.
Patricia G. Wolf, Saravanan Devendran, Heidi L. Doden, Lindsey K. Ly, Tyler Moore, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Genta Kakiyama, Purna Kashyap, Vance J. McCracken, H. Rex Gaskins, Patrick M. Gillevet, Jason M. Ridlon   +16 more
doaj   +1 more source

Bile acid patterns in commercially available oxgall powders used for the evaluation of the bile tolerance ability of potential probiotics. [PDF]

PLoS ONE, 2018
This study aimed to analyze the bile acid patterns in commercially available oxgall powders used for evaluation of the bile tolerance ability of probiotic bacteria.
Peng-Li Hu, Ya-Hong Yuan, Tian-Li Yue, Chun-Feng Guo   +3 more
doaj   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Gut Microbes, 2020
The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus Clostridium that are capable of generating secondary bile ...
Jason M. Ridlon, Saravanan Devendran, João Mp Alves, Heidi Doden, Patricia G. Wolf, Gabriel V. Pereira, Lindsey Ly, Alyssa Volland, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Alvaro G. Hernandez, Christopher J. Fields, Christy L. Wright, Genta Kakiyama, Isaac Cann, Purna Kashyap, Vance McCracken, H. Rex Gaskins   +21 more
doaj   +1 more source