Results 1 to 10 of about 196,945 (261)

Bile Acid Detection Techniques and Bile Acid-Related Diseases

Frontiers in Physiology, 2022
Bile acid is a derivative of cholinergic acid (steroidal parent nucleus) that plays an important role in digestion, absorption, and metabolism. In recent years, bile acids have been identified as signaling molecules that regulate self-metabolism, lipid ...
Xiang Zhao, Zitian Liu, Fuyun Sun, Lunjin Yao, Guangwei Yang, Kexin Wang   +5 more
doaj   +3 more sources

Sevelamer inhibits the formation of cholesterol gallstones by modulating bile acid metabolism [PDF]

Frontiers in Pharmacology
BackgroundThe purpose of this study was to investigate the effect and mechanism of Sevelamer hydrochloride (Sev) on cholesterol gallstone formation via the intestinal Fxr-Fgf15 signaling pathway in a mouse model.MethodsA cholesterol gallstone mouse model
Shuang Shen, Shuang Shen, Min Ning, Muhan Li, Shengnan Qian, Xin Ye, Qian Zhuang, Shan Wu, Xinjian Wan, Zhixia Dong   +9 more
doaj   +2 more sources

Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces

Journal of Lipid Research, 2022
Although most bile acids (BAs) in feces are present in noncovalent forms that can be extracted with ethanol, non-negligible amounts of saponifiable BAs are also present. It is a major concern that such saponifiable BAs are routinely omitted from fecal BA
Hajime Takei, Seiko Narushima, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Yuichiro Yamashiro, Hiroshi Nittono   +7 more
doaj   +1 more source

Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes

Hepatology Communications, 2021
Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [SLCO1B1]) and OATP1B3 (SLCO1B3) serve as transporters for hepatic uptake of important endogenous substances and several commonly ...
Akihiko Kimura, Tatehiro Kagawa, Hajime Takei, Yoshihiro Maruo, Hiroshi Sakugawa, Takahiro Sasaki, Tsuyoshi Murai, Nakayuki Naritaka, Hajime Takikawa, Hiroshi Nittono   +9 more
doaj   +1 more source

Profiling of Urinary Glucuronidated Bile Acids across Age Groups

Metabolites, 2022
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, Hiroshi Nittono   +6 more
doaj   +1 more source

Dietary Bile Acid Supplementation Could Regulate the Glucose, Lipid Metabolism, and Microbiota of Common Carp (Cyprinus carpio L.) Fed with a High-Lipid Diet

Aquaculture Nutrition, 2023
This study sought to examine the role of bile acids in the regulation of glucose and lipid metabolism, intestinal flora, and growth in high-fat diet-fed common carp (Cyprinus carpio L.). Fish (6.34±0.07 g) were fed for 56 days with three different diets,
Liping Yang, Mingyu Liu, Mengjuan Zhao, Shaoyang Zhi, Wenlei Zhang, Leya Qu, Jinrui Xiong, Xiao Yan, Chaobin Qin, Guoxing Nie, Shengpeng Wang   +10 more
doaj   +1 more source

Berberine alters gut microbial function through modulation of bile acids

BMC Microbiology, 2021
Background Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient lipid profiles.
Patricia G. Wolf, Saravanan Devendran, Heidi L. Doden, Lindsey K. Ly, Tyler Moore, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Genta Kakiyama, Purna Kashyap, Vance J. McCracken, H. Rex Gaskins, Patrick M. Gillevet, Jason M. Ridlon   +16 more
doaj   +1 more source

Bile acid transporters [PDF]

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation.
Paul A. Dawson, Tian Lan, Anuradha Rao
openaire   +3 more sources

A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS[S]

Journal of Lipid Research, 2014
We have developed a simple and accurate HPLC method for measurement of fecal bile acids using phenacyl derivatives of unconjugated bile acids, and applied it to the measurement of fecal bile acids in cirrhotic patients.
Genta Kakiyama, Akina Muto, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, Alan F. Hofmann, William M. Pandak, Jasmohan S. Bajaj   +8 more
doaj   +1 more source

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Gut Microbes, 2020
The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus Clostridium that are capable of generating secondary bile ...
Jason M. Ridlon, Saravanan Devendran, João Mp Alves, Heidi Doden, Patricia G. Wolf, Gabriel V. Pereira, Lindsey Ly, Alyssa Volland, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Alvaro G. Hernandez, Christopher J. Fields, Christy L. Wright, Genta Kakiyama, Isaac Cann, Purna Kashyap, Vance McCracken, H. Rex Gaskins   +21 more
doaj   +1 more source