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Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]
Frontiers in Medicine, 2020 In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Vik Meadows +7 more
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Gut Microbes, 2020 The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus Clostridium that are capable of generating secondary bile ...
Jason M. Ridlon +21 more
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Annals of Hepatology, 2017 The primary bile acids (BAs) are synthetized from colesterol in the liver, conjugated to glycine or taurine to increase their solubility, secreted into bile, concentrated in the gallbladder during fasting, and expelled in the intestine in response to dietary fat, as well as bio-transformed in the colon to the secondary BAs by the gut microbiota ...
Agostino Di Ciaula +6 more
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FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption [PDF]
Journal of Lipid Research, 2007 Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea, is characterized by a vicious cycle in which the feedback regulation of bile acid synthesis is interrupted, resulting in additional bile acid production.
Diana Jung +6 more
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Cholestyramine treatment in two dogs with presumptive bile acid diarrhoea: a case report [PDF]
Canine Medicine and Genetics, 2021 Background In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome.
L. Toresson +2 more
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Bile Acid Detection Techniques and Bile Acid-Related Diseases
Frontiers in Physiology, 2022 Bile acid is a derivative of cholinergic acid (steroidal parent nucleus) that plays an important role in digestion, absorption, and metabolism. In recent years, bile acids have been identified as signaling molecules that regulate self-metabolism, lipid ...
Xiang Zhao +5 more
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Recent advances in understanding bile acid homeostasis [version 1; referees: 2 approved]
F1000Research, 2017 Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G ...
John YL Chiang
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Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
Lipids in Health and Disease, 2018 Background Recently, trimethylamine-N-oxide (TMAO) plasma levels have been proved to be associated with atherosclerosis development. Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess ...
Lin Ding +7 more
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Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes
Hepatology Communications, 2021 Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [SLCO1B1]) and OATP1B3 (SLCO1B3) serve as transporters for hepatic uptake of important endogenous substances and several commonly ...
Akihiko Kimura +9 more
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