Results 11 to 20 of about 5,534,791 (400)

Systematic identification of secondary bile acid production genes in global microbiome [PDF]

mSystems
Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes ...
Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao   +11 more
doaj   +2 more sources

Identification of molecular subtypes based on bile acid metabolism in cholangiocarcinoma [PDF]

BMC Cancer
Background Cholangiocarcinoma is a highly heterogeneous tumor with bile acid metabolism involving in its development. The aim of this study was to characterize bile acid metabolism and identify specific subtypes to better stratify cholangiocarcinoma ...
Mingxia Deng, Jing Liu, Li Zhang, Yan Lou, Yunqing Qiu   +4 more
doaj   +2 more sources

Profiling of Urinary Glucuronidated Bile Acids across Age Groups

Metabolites, 2022
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, Hiroshi Nittono   +6 more
doaj   +1 more source

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Nature, 2021
Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases1–3. Here we show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating ...
Y. Sato, K. Atarashi, D. Plichta, Y. Arai, Satoshi Sasajima, Sean M. Kearney, W. Suda, Kozue Takeshita, Takahiro Sasaki, Shoki Okamoto, Ashwin N. Skelly, Yuki Okamura, H. Vlamakis, Youxian Li, Takeshi Tanoue, H. Takei, H. Nittono, S. Narushima, J. Irie, H. Itoh, K. Moriya, Y. Sugiura, M. Suematsu, Nobuko Moritoki, S. Shibata, D. Littman, M. Fischbach, Y. Uwamino, Takashi Inoue, A. Honda, M. Hattori, T. Murai, R. Xavier, N. Hirose, K. Honda   +34 more
semanticscholar   +1 more source

Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice

Nature Communications, 2022
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient ...
Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Meilin Wei, C. Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, A. Zhao, Cheng Hu, Chengxing Shen, W. Jia, Ping Liu, Xiaojiao Zheng, W. Jia   +19 more
semanticscholar   +1 more source

Human gut bacteria produce TH17-modulating bile acid metabolites

bioRxiv, 2021
The microbiota plays a pivotal role in gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17a (TH17 cells).
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, G. D’Agostino, Eunha Kim, E. Franzosa, J. Ávila-Pacheco, J. Bisanz, Christopher K. Rakowski, H. Vlamakis, R. Xavier, P. Turnbaugh, R. Longman, Michael R Krout, C. Clish, C. Huttenhower, Jun R. Huh, A. Devlin   +18 more
semanticscholar   +1 more source

Dietary Bile Acid Supplementation Could Regulate the Glucose, Lipid Metabolism, and Microbiota of Common Carp (Cyprinus carpio L.) Fed with a High-Lipid Diet

Aquaculture Nutrition, 2023
This study sought to examine the role of bile acids in the regulation of glucose and lipid metabolism, intestinal flora, and growth in high-fat diet-fed common carp (Cyprinus carpio L.). Fish (6.34±0.07 g) were fed for 56 days with three different diets,
Liping Yang, Mingyu Liu, Mengjuan Zhao, Shaoyang Zhi, Wenlei Zhang, Leya Qu, Jinrui Xiong, Xiao Yan, Chaobin Qin, Guoxing Nie, Shengpeng Wang   +10 more
doaj   +1 more source

Bile Acid–Gut Microbiota Axis in Inflammatory Bowel Disease: From Bench to Bedside

Nutrients, 2021
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear.
Min Yang, Y. Gu, Lingfu Li, Tianyu Liu, Xueli Song, Yue Sun, Xiaocang Cao, Bangmao Wang, Kui Jiang, H. Cao   +9 more
semanticscholar   +1 more source

Bile acid transporters [PDF]

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation.
Tian Lan, Paul A. Dawson, Anuradha Rao
openaire   +4 more sources

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.

Cell Host and Microbe, 2020
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in intestinal inflammation, we performed metabolomic, microbiome, metagenomic,
S. Sinha, Yeneneh Haileselassie, L. Nguyen, C. Tropini, Min Wang, L. Becker, Davis L. Sim, Karolin Jarr, Estelle T. Spear, Gulshan Singh, H. Namkoong, K. Bittinger, M. Fischbach, J. Sonnenburg, Aida Habtezion   +14 more
semanticscholar   +1 more source