Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]
, 2010 Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti +29 more
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Hepatic bile acid uptake: effect of conjugation, hydroxyl and keto groups, and albumin binding
Journal of Lipid Research, 1982 Hepatic extraction of trihydroxy (free, glyco- and tauro-conjugated) dihydroxy, and monohydroxy bile acids has been evaluated in single pass liver perfusion experiments in rats.
R Aldini +5 more
doaj +1 more source
Bile Acids Conjugation in Human Bile Is Not Random: New Insights from 1H-NMR Spectroscopy at 800 MHz [PDF]
, 2009 Bile acids constitute a group of structurally closely related molecules and represent the most abundant constituents of human bile. Investigations of bile acids have garnered increased interest owing to their recently discovered additional biological ...
Cooper, Amanda +4 more
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FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption
Journal of Lipid Research, 2007 Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea, is characterized by a vicious cycle in which the feedback regulation of bile acid synthesis is interrupted, resulting in additional bile acid production.
Diana Jung +6 more
doaj +1 more source
Diversification of host bile acids by members of the gut microbiota
Gut Microbes, 2020 Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol.
Jenessa A. Winston, Casey M. Theriot
doaj +1 more source
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]
, 2018 The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan +5 more
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Recent advances in understanding bile acid homeostasis [version 1; referees: 2 approved]
F1000Research, 2017 Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G ...
John YL Chiang
doaj +1 more source
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]
, 2011 Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A +21 more
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Journal of Lipid Research, 2000 We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu +13 more
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Strain differences in deconjugation of bile acids in Bifidobacterium pseudocatenulatum isolates [PDF]
, 2004 The survival and growth rate of twenty eight isolates of bifidobacteria in bile were evaluated. Of 28 isolates, 25 were tolerance towards 2.0% concentration of bile while 14 isolates were tolerance towards 4.0% of bile after 12 hours of exposure.
Abd Manap, Mohd Yazid +8 more
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