Results 21 to 30 of about 5,534,791 (400)

Berberine alters gut microbial function through modulation of bile acids

BMC Microbiology, 2021
Background Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient lipid profiles.
Patricia G. Wolf, Saravanan Devendran, Heidi L. Doden, Lindsey K. Ly, Tyler Moore, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Genta Kakiyama, Purna Kashyap, Vance J. McCracken, H. Rex Gaskins, Patrick M. Gillevet, Jason M. Ridlon   +16 more
doaj   +1 more source

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Nature, 2020
The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around
Masanori Funabashi, T. Grove, Min Wang, Yug Varma, Molly E. McFadden, Laura C. Brown, Chun-Jun Guo, S. Higginbottom, S. Almo, M. Fischbach   +9 more
semanticscholar   +1 more source

Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis

Alimentary Pharmacology and Therapeutics, 2021
Bile acids are important endocrine modulators of intestinal and hepatic signalling cascades orchestrating critical pathophysiological processes in various liver diseases.
B. Simbrunner, M. Trauner, T. Reiberger
semanticscholar   +1 more source

Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice [PDF]

Journal of Lipid Research, 2010
An improved ultra performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) method was established for the simultaneous analysis of various bile acids (BA) and applied to investigate liver BA content in C57BL/6 mice fed 1% cholic acid (CA), 0.3% deoxycholic acid (DCA), 0.3% chenodeoxycholic acid (CDCA), 0.3% lithocholic acid (LCA), 3 ...
Youcai Zhang, Curtis D. Klaassen
openaire   +3 more sources

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020
Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for maintaining whole body cholesterol homeostasis. Bile acids are physiological detergents that absorb, distribute, metabolize and excrete nutrients, drugs and ...
J. Chiang, Jessica M. Ferrell
semanticscholar   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. [PDF]

, 2018
BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia.
Bao, X, Brito, H, Moura-Santos, P, Oliveira, A, et al., Palmela, C, Ruiqi, H, Silva, J, Torres, J   +7 more
core   +1 more source

Bile acid metabolites control Th17 and Treg cell differentiation

bioRxiv, 2018
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Saiyu Hang, Donggi Paik, Lina Yao, Eunha Kim, Jamma Trinath, Jingping Lu, Soyoung Ha, Brandon N. Nelson, Samantha P. Kelly, Lin Wu, Ye Zheng, R. Longman, F. Rastinejad, A. Devlin, Michael R Krout, M. Fischbach, D. Littman, D. Littman, Jun R. Huh, Jun R. Huh   +19 more
semanticscholar   +2 more sources

Bile acid patterns in commercially available oxgall powders used for the evaluation of the bile tolerance ability of potential probiotics. [PDF]

PLoS ONE, 2018
This study aimed to analyze the bile acid patterns in commercially available oxgall powders used for evaluation of the bile tolerance ability of probiotic bacteria.
Peng-Li Hu, Ya-Hong Yuan, Tian-Li Yue, Chun-Feng Guo   +3 more
doaj   +1 more source

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]

, 2011
Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A, Batzri S, Beuers U, Beuers U, Douglas M. Jefferson, Duane WC, Eastwood GL, Hofmann AF, Hohenester S, Hov JR, Lucas Maillette de Buy Wenniger, Medina JF, Melero S, Minagawa N, Poupon R, Prieto J, Prieto J, Ronald P. Oude Elferink, Rust C, Simon Hohenester, Spivey JR, Ulrich Beuers   +21 more
core   +1 more source