Bile Acid Signaling in Inflammatory Bowel Diseases
Digestive Diseases and Sciences, 2020 Bile acids are a group of chemically different steroids generated at the host/microbial interface. Indeed, while primary bile acids are the end-product of cholesterol breakdown in the host liver, secondary bile acids are the products of microbial ...
S. Fiorucci +7 more
semanticscholar +1 more source
Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]
, 2017 Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef +7 more
core +3 more sources
Bile Acid Signaling in Neurodegenerative and Neurological Disorders
International Journal of Molecular Sciences, 2020 Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids in the gastrointestinal track during normal physiological conditions as well as hepatic and cholestatic diseases have been well studied.
S. Grant, S. DeMorrow
semanticscholar +1 more source
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S. +5 more
core +1 more source
Hepatology, 2020 Cholestatic liver disease is characterized by gut dysbiosis and excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA synthesis are potential strategies for the treatment of cholestatic liver disease.
Yunhuan Liu +15 more
semanticscholar +1 more source
Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells [PDF]
, 2009 In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower
Alan F. Hofmann +45 more
core +1 more source
Journal of Lipid Research, 2022 Although most bile acids (BAs) in feces are present in noncovalent forms that can be extracted with ethanol, non-negligible amounts of saponifiable BAs are also present. It is a major concern that such saponifiable BAs are routinely omitted from fecal BA
Hajime Takei +7 more
doaj
Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]
Advances in Virology Volume 2011 (2011), Article ID 262080, 11
pages, 2010 Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved. Here, by employing systems biology approach, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic ...
arxiv +1 more source
Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis [PDF]
, 2019 Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metabolic
Abu‐Hayyeh S +39 more
core +4 more sources