REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression [PDF]
arXiv, 2023 Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments.
arxiv
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]
, 2008 Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U. +5 more
core +1 more source
Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.
Hepatobiliary surgery and nutrition, 2020 Bile acids are synthesized from cholesterol only in hepatocytes. Bile acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in ...
Tiangang Li, J. Chiang
semanticscholar +1 more source
Diversification of host bile acids by members of the gut microbiota
Gut Microbes, 2020 Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host hepatocytes synthesize primary bile acids from cholesterol.
Jenessa A. Winston, Casey M. Theriot
doaj +1 more source
Microbiome-derived bile acids contribute to elevated antigenic response and bone erosion in rheumatoid arthritis [PDF]
arXiv, 2023 Rheumatoid arthritis (RA) is a chronic, disabling and incurable autoimmune disease. It has been widely recognized that gut microbial dysbiosis is an important contributor to the pathogenesis of RA, although distinct alterations in microbiota have been associated with this disease.
arxiv
Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]
, 1992 Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Abell +59 more
core +1 more source
Bile dynamics within the biliary tract and microfluidic-based bile component detection: A review [PDF]
arXiv, 2023 Bilestones are solid masses found in the gallbladder or biliary tract, which block the normal bile flow and eventually result in severe life-threatening complications. Studies have shown that bilestone formation may be related to bile flow dynamics and the concentration level of bile components.
arxiv
Bile acids and bile alcohols of bullfrog.
Journal of Lipid Research, 1980 Gallbladder bile of the bullfrog, Rana cetesbeiana was found to contain a number of minor bile acids and bile alcohols in unconjugated forms. The following bile acids and bile alcohols were identified by combined gas-liquid chromatography-mass spectrometry: cholic acid, allocholic acid, 3 alpha,7 alpha,12 alpha-trihydroxy-5 alpha-cholestan-26-oic acid,
Minori Yasuda +5 more
openaire +4 more sources
Formulation of a live bacterial vaccine for stable room temperature storage results in loss of acid, bile and bile salt resistance [PDF]
, 2008 Live bacterial vaccines have great promise both as vaccines against enteric pathogens and as heterologous antigen vectors against diverse diseases. Ideally, room temperature stable dry formulations of live bacterial vaccines will allow oral vaccination ...
Edwards, Alexander D. +1 more
core +1 more source
A positive SeHCAT test results in fewer subsequent investigations in patients with chronic diarrhoea. [PDF]
, 2017 Chronic diarrhoea is a common condition, resulting from a number of different disorders. Bile acid diarrhoea, occurring in about a third of these patients, is often undiagnosed.
Appleby, RN +3 more
core +1 more source