Results 211 to 220 of about 39,146 (248)
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Biochemistry, 1992
To conclude, the last several years have seen a resurgence of interest in the biosynthesis of bile acids. This focus has come about due to the central roles that these molecules play in cholesterol and fat metabolism and due to recent advances in their chemistry, biochemistry, and molecular biology.
David W Russell, Kenneth D R Setchell
exaly +3 more sources
To conclude, the last several years have seen a resurgence of interest in the biosynthesis of bile acids. This focus has come about due to the central roles that these molecules play in cholesterol and fat metabolism and due to recent advances in their chemistry, biochemistry, and molecular biology.
David W Russell, Kenneth D R Setchell
exaly +3 more sources
REGULATION OF BILE ACID BIOSYNTHESIS [PDF]
Gastroenterology Clinics of North America, 1999 This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynthestic pathways is discussed. The important role of these pathways in the maintenance of cholesterol homeostasis and the possible therapeutic implications for the treatment of hypercholesterolemia are ...
Z R, Vlahcevic +2 more
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Biosynthesis of bile acids in mammalian liver
European Journal of Drug Metabolism and Pharmacokinetics, 2006The biosynthesis of bile acids in mammalian liver and its regulation, together with the physiological role of bile acids, are reviewed in this article. Bile acids are biosynthesized from cholesterol in hepatocytes. Several steps are involved including epimerisation of the 3beta-hydroxyl group, reduction of the delta4 double bond to the 5beta-H ...
S, Kevresan +4 more
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Hydroxylations in biosynthesis and metabolism of bile acids
Molecular and Cellular Biochemistry, 1974Recent development in research concerning hydroxylations in biosynthesis and metabolism of bile acids is reviewed. In the conversion of cholesterol into bile acids, hydroxyl groups may be introduced into the following positions: C-6α, C-6β, C-7α, C-12α, C-16α, C-23, C-24, C-25, and C-26.
I, Björkhem, H, Danielsson
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Defects in Bile Acid Biosynthesis‐Diagnosis and Treatment
Journal of Pediatric Gastroenterology and Nutrition, 2006ABSTRACTBile acid synthetic defects represent a specific category of metabolic liver disease. This article highlights the history and summarizes our analytical approach to the diagnosis and treatment of genetic defects in bile acid synthesis. By the application of mass spectrometry as a screening tool, it is possible to perform rapid diagnosis of ...
Kenneth D R, Setchell, James E, Heubi
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Mechanisms of Bile Acid Biosynthesis
1973In this chapter, an attempt is made to summarize present knowledge concerning the mechanisms of the conversion of cholesterol into the primary bile acids. In addition, a section on the formation of bile salts in “primitive” animals is included. Emphasis in discussion and documentation of references will be placed on more recent developments.
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Two 7α‐hydroxylase enzymes in bile acid biosynthesis
Current Opinion in Lipidology, 1998The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that ...
M, Schwarz, E G, Lund, D W, Russell
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Role of peroxisomes in the biosynthesis of bile acids.
Scandinavian journal of clinical and laboratory investigation. Supplementum, 1985Evidence is presented that peroxisomes are more important than other subcellular fractions in rat liver for the final reactions in the biosynthesis of cholic acid from cholesterol. The peroxisomal conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) into cholic acid was studied in detail and optimal assay conditions were ...
I, Björkhem, B F, Kase, J I, Pedersen
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The Biosynthesis of Bile Acids
Scottish Medical Journal, 1973I W, Percy-Robb, G S, Boyd
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