Results 221 to 230 of about 3,456,901 (302)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Gut microbiota contributes to gestational diabetes mellitus by interfering with bile acid metabolism and resistin. [PDF]

Front Cell Infect Microbiol
Huang J, Zhang Y, Zheng W, Li G.
europepmc   +1 more source

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

Alcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolism. [PDF]

JHEP Rep
Keller MI, de Zawadzki A, Thiele M, Suvitaival T, Sulek K, Kuhn M, Schudoma C, Podlesny D, Nishijima S, Fullam A, Kim CY, Niu L, Wretlind A, Hansen JK, Israelsen M, Johansen S, Akanni W, Hazenbrink D, Juel HB, Mann M, Hansen T, Krag A, Bork P, Legido-Quigley C, GALAXY & MicrobLiver consortia.   +24 more
europepmc   +1 more source

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

Exploration, EarlyView.
Inspired by the germination of probiotic spores, we utilize the excellent characteristics of spores to break through multiple barriers of oral brain‐targeted delivery. Besides the probiotics mediated gut‐brain communication, the spore coat proteins derived nanosystems with multiple‐barriers‐crossing ability alleviate neurodegeneration.
Qianhua Feng, Yuying Mei, Jia Zhang, Liying Sun, Bingqian Si, Huimin Zhou, Huifang Xiao, Runhan Liu, Jieyun Zhang, Lei Wang   +9 more
wiley   +1 more source

Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway. [PDF]

Chin Med
Jiang ZX, Chen XL, Sun Q, Yang LC, Zhang YW, Wu Q, Yao HC, Zhang D, Yuan LW.   +8 more
europepmc   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

FlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue, Wanqi Yang, Xiaoyu Liu, Xuehui Chu, Wei Li, Jinglin Wang   +5 more
wiley   +1 more source

Dietary Fiber Regulation of Gut Microbiota and Bile Acid Metabolism in Animals: Implications for Animal Nutrition. [PDF]

Vet Sci
Lai J, Zentek J, Grześkowiak ŁM.
europepmc   +1 more source

Interactions of delivery systems modulating the digestibility of plant‐based proteins

Food Biomacromolecules, EarlyView.
Abstract Plant‐based proteins are gaining interest as sustainable alternatives to animal‐derived proteins, but their digestibility is often lower and strongly influenced by protein structure, processing history, and food‐matrix interactions. This review critically examines how emulsions, hydrogels, micro‐ and nanoparticles, micelles, liposomes ...
Samina Kauser, Sana Imtiaz, Emaan Shahid, Aneela Yar, Asma Ayub, Muhammad Umar   +5 more
wiley   +1 more source

<i>Bacillus coagulans</i> Improves Performance by Modulating Bile Acid Metabolism to Suppress Hepatic Lipid Accumulation and Attenuating Ovarian Oxidative Stress in Late Laying Hens. [PDF]

Animals (Basel)
Guo S, Lv Z, Duan Y, Peng B, Niu J, Guo Y, Wang Z, Zhang W.   +7 more
europepmc   +1 more source