Results 201 to 210 of about 87,670 (247)

Preclinical Efficacy and Safety Evaluation of a Novel Controlled‐Expansion ePTFE‐Covered TIPS Stent in a Swine Model

Portal Hypertension &Cirrhosis, EarlyView.
This preclinical study evaluated a novel controlled‐expansion expanded polytetrafluoroethylene (ePTFE)‐covered transjugular intrahepatic portosystemic shunt (TIPS) stent in 11 swine, demonstrating 100% technical success, excellent deployability, and durable 6‐month angiographic patency without thrombosis, migration, fracture, or device‐related toxicity.
Yi Xiang, Qi Zhang, Chuan Liu, Jiawei Zhang, Qingqiao Zhang, Changsheng Shi, Chunze Zhou, Yudong Zhang, Hongliang He, Hao Xie, Hui Shi, Haijian Guo, Wenjing Liu, Muqing Lin, Huajie Yu, Xiaolong Qi   +15 more
wiley   +1 more source

HvarAKR1B1‐mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation

Pest Management Science, EarlyView.
Starvation stress significantly affected the growth and development of Hippodamia variegata. Combined transcriptome and metabolome analysis and RNA interference verification revealed that HvarAKR1B1 may be involved in the response of Hippodamia variegata to starvation stress.
Bing‐mei Song, De‐qin Hu, Yuan Li, Wang‐quan Jiao, Xiao‐li Ma, Hong‐sheng Pan   +5 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Bile Acid Synthesis

Annual Review of Physiology, 1983
Cholesterol is the obligatory precursor of bile acids, and the liver is the sole source and site of bile acid formation (1). In the transformation of choles­ terol to bile acids, the cyclopentanophenanthrene nucleus is first believed to undergo modifications followed by oxidation and cleavage of the choles­ terol side-chain.
G, Salen, S, Shefer
openaire   +2 more sources

Regulation of bile acid synthesis

Hepatology, 1991
HEPATIC CHOLESTEROL HOMEOSTASIS The liver plays a central role in the regulation of cholesterol homeostasis. Under normal conditions, cholesterol input into the body equals output; cholesterol homeostasis is maintained. Under pathologic conditions, enhancement of cholesterol input into the liver or a reduction in hepatic cholesterol output may ...
Z R, Vlahcevic, D M, Heuman, P B, Hylemon   +2 more
openaire   +2 more sources

Bile acids: LXI. Synthesis and properties of conjugates of 5α‐bile acids

Lipids, 1980
AbstractAllo bile acids and their taurine‐ and glycine‐conjugates were synthesized by modification of existing procedures. Their chromatographic and spectral properties were investigated and compared with the 5β‐analogs. Some of the naturally occurring 5α‐ and 5β‐conjugates were separable by high performance liquid chromatography via straight‐phase ...
R, Shaw, W H, Elliott
openaire   +2 more sources

Synthesis of sulfonate analogs of bile acids

Steroids, 1992
Sulfonate analogs of C23 and C24 bile acids were synthesized from norcholic, norchenodeoxycholic, norursodeoxycholic, nordeoxycholic, norhyodeoxycholic, cholic, deoxycholic, hyodeoxycholic, and lithocholic acids. The principal reactions used were (1) reduction of the bile acids with NaBH4 to the corresponding bile alcohols, (2) selective tosylation of ...
K, Kihira, T, Mikami, S, Ikawa, A, Okamoto, M, Yoshii, S, Miki, E H, Mosbach, T, Hoshita   +7 more
openaire   +2 more sources

Metabolic pathways of bile acid synthesis

The American Journal of Medicine, 1971
Abstract The major pathway for the metabolism and excretion of cholesterol in mammals is the formation of acidic steroids in the liver. Although in principle the theme is the same, there are variations that make different species quite distinctive. Man synthesizes only two primary bile acids and conjugates each of these with either glycine or taurine ...
W H, Elliott, P M, Hyde
openaire   +2 more sources