Results 201 to 210 of about 4,927,968 (256)

Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. [PDF]

J Biol Chem, 2022
Kouno T, Liu X, Zhao H, Kisseleva T, Cable EE, Schnabl B.   +5 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion. [PDF]

Int J Biol Sci
Pan Z, Jin X, Li Q, Zhou Y, Zeng Y, Wang X, Jin Y, Chen Y, Li D, Ling W.   +9 more
europepmc   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. [PDF]

Science
Varanasi SK, Chen D, Liu Y, Johnson MA, Miller CM, Ganguly S, Lande K, LaPorta MA, Hoffmann FA, Mann TH, Teneche MG, Casillas E, Mangalhara KC, Mathew V, Sun M, Jensen IJ, Farsakoglu Y, Chen T, Parisi B, Deota S, Havas A, Lee J, Chung HK, Schietinger A, Panda S, Williams AE, Farber DL, Dhar D, Adams PD, Feng GS, Shadel GS, Sundrud MS, Kaech SM.   +32 more
europepmc   +1 more source

Standardized Research Methodology for Akkermansia muciniphila: Multi‐Omics Integration, Functional Evaluation, and Clinical Translation Pathways

Gut Medicine, EarlyView.
ABSTRACT Background Akkermansia muciniphila has emerged as a leading next‐generation beneficial microbe candidate in gut microbiome research, linked to host metabolic homeostasis, mucosal immune regulation, and intestinal barrier integrity. However, marked methodological heterogeneity in isolation and culture conditions, detection and quantification ...
Jiaxin Chen, Mantang Qiu
wiley   +1 more source

Restoration of intestinal secondary bile acid synthesis: A potential approach to improve pancreatic β cell function in type 1 diabetes. [PDF]

Cell Rep Med
Liu Q, Hua Y, He R, Xiang L, Li S, Zhang Y, Chen R, Qian L, Jiang X, Wang C, Wang C, Li Y, Wu H, Liu Y.   +13 more
europepmc   +1 more source

The clinical and biochemical effectiveness and safety of cholic acid treatment for bile acid synthesis defects: a systematic review. [PDF]

Orphanet J Rare Dis
Polak Y, van Dussen L, Kemper EM, Vaz FM, Klouwer FCC, Engelen M, Hollak CEM.   +6 more
europepmc   +1 more source

GOLM1 and bile acid synthesis: Correspondence to editorial on "GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers". [PDF]

Clin Mol Hepatol
Li YT, Shao WQ, Chen ZM, Lin J, Chen JH.
europepmc   +1 more source

Hepatic SIRT6 protects against cholestatic liver disease primarily <i>via</i> inhibiting bile acid synthesis. [PDF]

J Biomed Res
Zhang W, Wang J, Yang L, Shao Y, Peng H, Jiang L, Sheng L.   +6 more
europepmc   +1 more source