Results 211 to 220 of about 87,670 (247)
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Disorders of Bile Acid Synthesis
Journal of Inherited Metabolic Disease, 2000AbstractInborn errors of bile acid synthesis can produce life‐threatening cholestatic liver disease (which usually presents in infancy) and progressive neurological disease presenting later in childhood or in adult life. Both types of disease can often be treated very effectively with bile acid replacement therapy and it is therefore important to ...
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Enzymatic regulation of bile acid synthesis
The American Journal of Medicine, 1971Abstract The conversion of cholesterol to bile acids involves the participation of various types of enzymes. These include different mono-oxygenases, dehydrogenases, isomerases, reductases, etc., together with various co-factors such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), nicotinamide adenine dinucleotide (NAD+) and coenzyme A
G S, Boyd, I W, Percy-Robb
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Regulation of bile acid synthesis
Frontiers in Bioscience, 1998Bile acids are important physiological agents required for disposal of cholesterol and absorption of vitamins and fats. Bile acids are synthesized from cholesterol in the liver. Enterohepatic circulation of bile acids is very efficient and plays an important physiological role in lipid absorption and secretion, and regulation of bile acid biosynthesis ...
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Synthesis of Bile Acid Coenzyme A Thioesters in the Amino Acid Conjugation of Bile Acids
2005Bile acids are converted to their glycine and taurine N-acyl amidates by enzymes in the liver in a two-step process. This conjugation reaction increases the aqueous solubility of bile acids, particularly in the acidic environment of the initial portion of the small intestine. In the first step, bile acid coenzyme A (CoA) thioesters are formed by a bile
Erin M, Shonsey +6 more
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Hepatology, 1988
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7α-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile acid synthesis, seven ...
D M, Heuman +3 more
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Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7α-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile acid synthesis, seven ...
D M, Heuman +3 more
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Bile acids in asymmetric synthesis and chiral discrimination
Chirality, 2009AbstractAn overview on the use of bile acid‐based compounds able to catalyze transformations, control the stereochemical course of a given reaction, recognize and bind other molecules, is presented. The recent developments in inclusion discrimination of chiral and achiral guests and enantioselective recognition achieved by bile acid are described with ...
BORTOLINI, Olga +2 more
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Regulation of Bile Acid Synthesis
1974Bile acids formed from cholesterol in the liver are defined as “primary” bile acids. In man, these are chenodeoxycholic acid and cholic acid. Following conjugation with glycine or taurine the bile acids are secreted into the bile and stored in the gallbladder.
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Bile acid synthesis: down-regulation by monohydroxy bile acids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1988The regulation of bile acid synthesis was studied in rabbits after interruption of the enterohepatic circulation by choledochoureteral anastomosis. Total daily bile acid output was 772 +/- 130 (SD) mumol/24 h, of which greater than 95% was glycocholic acid. Administration of deoxycholic or cholic acid or their conjugates (300-800 mumol) or gall-bladder
R, Hall, E, Kok, N B, Javitt
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Bile acid synthesis in humans.
Cancer research, 1981Metabolic pathways involved in the conversion of cholesterol to cholic and chenodeoxycholic acids have been investigated in bile fistula patients treated with a number of labeled potential bile acid intermediates. The findings of the present report indicate that the human liver cell has the capacity to synthesize both primary bile acids via multiple ...
L, Swell +5 more
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2023
<p>Bile acids are steroid structures with a carboxylic acid alkyl chain that are synthesised from cholesterol in the liver and function to regulate metabolism. They are mainly used as surfactants in the solubilization of lipids but they can also be used as cell signalling molecules targeting TGR5 and FXR receptors which have been implicated as ...
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<p>Bile acids are steroid structures with a carboxylic acid alkyl chain that are synthesised from cholesterol in the liver and function to regulate metabolism. They are mainly used as surfactants in the solubilization of lipids but they can also be used as cell signalling molecules targeting TGR5 and FXR receptors which have been implicated as ...
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