Results 101 to 110 of about 234,802 (359)

Pharmacological Applications of Bile Acids and Their Derivatives in the Treatment of Metabolic Syndrome [PDF]

, 2018
Apart from well-known functions of bile acids in digestion and solubilization of lipophilic nutrients and drugs in the small intestine, the emerging evidence from the past two decades identified the role of bile acids as signaling, endocrine molecules ...
Adorini, Aguilar, Ajouz, Al-Salami, Al-Salami, Alpert, Amaral, Ashby, Baghdasaryan, Bellanti, Benedict, Bradley, Brufau, Buchman, Carazo, Cariou, Chen, Chennamsetty, Chiang, Chiang, Chiang, Chun, Chung, Chung, Chávez-Talavera, Cipriani, Comeglio, Cybulsky, Danic, Dawson, de Boer, de Boer, De Giorgi, DeGruttola, Demir, Deutschmann, Duboc, Dutia, Everard, Fang, Feneberg, Ferrebee, Fickert, Fickert, Fiorucci, Fiorucci, Fiorucci, Fiorucci, Fiorucci, Fu, Gabbia, Gardmo, Garvey, Garvey, Gautier, Gerken, Gioiello, Goto, Gruben, Guo, Haeusler, Halilbasic, Han, Hanson, He, Hirschfield, Hofmann, Hofmann, Hou, Hylemon, Inagaki, Jansen, Jia, Jiao, Kang, Katona, Katsuma, Kaur, Kemper, Kida, Kitade, Knip, Kuhajda, Kumar, Kumar, Kuno, Lam, Lambert, Li, Li, Li, Li, Li, Li, Lobysheva, Madsbad, Madsbad, Maruyama, Maruyama, Massafra, McCracken, Mencarelli, Mendez-Sanchez, Mertens, Miao, Mikov, Mikov, Mikov, Mircioiu, Miyazaki-Anzai, Molinaro, Monte, Mudaliar, Mueller, Mullard, Nakahara, Neuschwander-Tetri, Nevens, Osto, Ozcan, Pan, Papazyan, Paumgartner, Pavek, Pavlovic, Pellicciari, Pellicciari, Pencek, Penney, Perez, Pols, Pournaras, Prinz, Qin, Quercia, Raghow, Ramirez-Perez, Renga, Renga, Ridlon, Roda, Roda, Rodrigues, Rosa, Ryan, Salehi, Sanyal, Sato, Schaap, Schoenfield, Shapiro, Shen, Shimizu, Sinisalo, Stanimirov, Stayrook, Stedman, Stedman, Steiner, Stojančević, Stojančević, Taoka, Thomas, Trauner, Uppal, Urizar, van Nierop, Vaz, Verbeke, Vrieze, Wahlstrom, Walsh, Walters, Wang, Wang, Watanabe, Wree, Yadav, Yamagata, Yang, Zhang, Zwicker   +181 more
core   +2 more sources

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

A proposed nomenclature for bile acids.

Journal of Lipid Research, 1992
A proposal is made for a system of nomenclature of the more common unconjugated and conjugated bile acids. Acceptable trivial names for bile acids are tabulated, and guidelines are proposed for using these existing trivial names as roots to create ...
AF Hofmann, J Sjövall, G Kurz, A Radominska, CD Schteingart, GS Tint, ZR Vlahcevic, KD Setchell   +7 more
doaj  

Purification of total flavonoids from Aurea Helianthus flowers and In Vitro Hypolipidemic Effect [PDF]

arXiv, 2019
The effects of purification methods and its hypolipidemic function on the total flavonoids of Aurea Helianthus flower were investigated. Liquid-liquid extraction of ethanol extract from Aurea Helianthus flower was carried out by using different polar solvents. The extract with the highest total flavonoid content was selected, and the optimal conditions
arxiv  

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

Model of pathogenesis of psoriasis. Part 1. Systemic psoriatic process [PDF]

arXiv, 2011
Analytical study of results of experimental and theoretical works on pathogenesis of psoriatic disease was conducted. Psoriasis is dermal implication of systemic psoriatic process (SPP). New SPP model explaining results of clinical and laboratory experiments was formulated.
arxiv  

Ascitic Bile Acids in Patients with Liver Cirrhosis [PDF]

, 1985
Ascitic bile acids of 8 patients with liver cirrhosis were analyzed in order to elucidate the clinical significance. The results were as follows. 1) Ascitic bile acid concentrations in intractable ascites were high, although low in tractable ascites. 2)
DOHI, Kiyohiko, EZAKI, Haruo, HARADA, Mitsuo, INAGAKI, Kazuo, TAKAHASHI, Makoto   +4 more
core  

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Preservation of conjugated primary bile acids by oxygenation of the small intestinal microbiota in vitro

mBio
Bile acids play a critical role in the emulsification of dietary lipids, a critical step in the primary function of the small intestine, which is the digestion and absorption of food.
Jenni Firrman, Elliot S. Friedman, Aaron Hecht, William C. Strange, Adrienne B. Narrowe, Karley Mahalak, Gary D. Wu, LinShu Liu   +7 more
doaj   +1 more source

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids [PDF]

, 2019
A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ...
Mazmanian, Sarkis, Quinn, Robert A., Thron, Taren   +2 more
core