Results 101 to 110 of about 238,773 (337)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Effect of bile acid deconjugation on the fecal excretion of steroids

Journal of Lipid Research, 1970
The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which ...
Thomas F. Kellogg, P. Leonard Knight, Bernard S. Wostmann   +2 more
doaj  

Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women [PDF]

, 2018
Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic changes. We assessed how rapid weight loss due to a
A Cotillard, A Damms-Machado, A Mardinoglu, A Wahlstrom, AC Vaughn, Adele Costabile, Alexandros Pechlivanis, AP Liou, AW Janssen, B Cariou, BE Lopez-Contreras, BJ Callahan, C Jiang, C Lozupone, CB Newgard, CD Simoes, D Festi, D McDonald, DP Faith, E Le Chatelier, ED Sonnenburg, F Ottosson, H Roytio, HK Pedersen, JA Holt, Jan L. Breslow, Jeanne M. Walker, JG Caporaso, JH Bottin, JJ Faith, JK Goodrich, JM Ridlon, JM Ridlon, JO Alemán, Joel Correa De Rosa, Jonathan R. Swann, José O. Alemán, JR Swann, JR Swann, K Katoh, KK Ryan, LA David, LM Cox, LM Nelson, M Lopez-Siles, M Monirujjaman, MA Stanislawski, Martin J. Blaser, MC Dao, MD Jensen, MH Sarafian, MJ Anderson, MN Price, NA Bokulich, NA Bokulich, NA Bokulich, Nicholas A. Bokulich, O Beckonert, P Elliott, P Lefebvre, Peter R. Holt, PH Bisschop, PJ Turnbaugh, R Kohli, R Liu, R Mathur, RA Haeusler, RC Pires, RE Ley, RO Kamrath, RR Henry, S Fiorucci, S Pendyala, SI Sayin, T Li, T Lundasen, T Sen, Thomas Battaglia, TN Kelly, Yupu Liang, ZD Fu   +80 more
core   +3 more sources

The Preparation of Some Carboxylabelled Bile Acids. Bile Acids and Steroids 2. [PDF]

, 1953
Sune Bergström, Max Rottenberg, Jacques Voltz, E. Schønfeldt, Inger Steensgaard, Th. Rosenberg   +5 more
openalex   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Occurrence and Metabolism of Chenodeoxycholic Acid in the Rat. Bile Acids and Steroids. 13. [PDF]

, 1954
Sune Bergström, Jan Sjövall, Roger Bonnichsen, John Rastrup Andersen   +3 more
openalex   +1 more source

Bile Acids

Journal of Biological Chemistry, 1971
Abstract 3β-3H-Allochenodeoxycholic acid was administered by stomach tube to rats with bile fistulas. Bile collected during the first 21 hours contained 53 to 59% of the administered 3H. After hydrolysis and separation of the free bile acids by acetic acid partition chromatography, 95% of the chromatographed 3H was recovered as the unchanged acid, but ...
Mei Mei Mui, William H. Elliott
openaire   +4 more sources

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases

Journal of Lipid Research, 1988
Unusual bile acids in umbilical cord blood and amniotic fluid of term newborns and in sera and urine from adult patients with cholestatic liver diseases were analyzed by use of gas-liquid chromatography-mass spectrometry.
J Shoda, R Mahara, T Osuga, M Tohma, S Ohnishi, H Miyazaki, N Tanaka, Y Matsuzaki   +7 more
doaj  

Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats [PDF]

, 2013
Background. Significant physiological changes occur during pregnancy and lactation. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease closely related to disruption of bile acid homeostasis.
Dan Zhang, Hong M. Xie, Jie Liu, Qiong N. Zhu, Yuan F. Lu   +4 more
core   +1 more source