Results 31 to 40 of about 29,638 (318)

Influence of the structure of bile acids on their partition coefficient in dibutyl ether and chloroform [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2015
Bile acids are well known natural surfactants able to modify the per­meability of biological membranes. The logarithm of partition coefficient between, tradi­tionally used, n-octanol and water is a measure of lipophilicity as a predictor of ...
Sebenji Ana S., Pоša Mihalj M., Grujić-Letić Nevena N., Popović Kosta J.   +3 more
doaj   +1 more source

Exposure of Barrett’s and esophageal adenocarcinoma cells to Bile acids activates EGFR-STAT3 signaling axis via induction of APE1

Oncogene, 2018
The development of Barrett’s esophagus (BE) and its progression to esophageal adenocarcinoma (EAC) is highly linked to exposure to acidic bile salts due to chronic gastroesophageal reflux disease (GERD).
A. Bhat, Heng Lu, M. Soutto, A. Capobianco, P. Rai, A. Zaika, W. El-Rifai   +6 more
semanticscholar   +1 more source

The regulatory mechanism of acidic tea polysaccharides from Wuyi rock tea on bile acids in type 2 diabetic rats

Shipin yu jixie
ObjectiveThis study aimed to investigate the effects of an acidic tea polysaccharide extracted from Wuyi Rock tea "yellow slice" on bile acids in hyperglycaemic rats.MethodsIn vitro experiments simulating artificial gastric and intestinal fluids were ...
WU Zhong, YANG Jiangfan
doaj   +1 more source

Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk

PLoS ONE, 2016
Disruptions to circadian rhythm in mice and humans have been associated with an increased risk of obesity and metabolic syndrome. The gut microbiota is known to be essential for the maintenance of circadian rhythm in the host suggesting a role for ...
K. Govindarajan, John Macsharry, P. G. Casey, F. Shanahan, S. Joyce, C. Gahan   +5 more
semanticscholar   +1 more source

Dependence of the biliary excretion of iopanoic acid on bile salts

Gastroenterology, 1978
Abstract Iopanoic acid is an iodinated organic acid used extensively as a radiographic contrast material for oral cholecystography. Like bilirubin, it is conjugated predominately with glucuronic acid in the liver, and the biliary excretion is enhanced by the concomitant biliary excretion of bile salts.
Peter M. Loeb, James L. Barnhart, Robert N. Berk   +2 more
openaire   +3 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c‐Myc expression

Cancer Medicine, 2017
c‐Myc overexpression has been implicated in several malignancies including gastric cancer. Here, we report that acidified bile acids enhance tumor progression and telomerase activity in gastric cancer via c‐Myc activation both in vivo and in vitro. c‐Myc
Xiaolong Wang, Lei Sun, Xi-jing Wang, Huafeng Kang, Xiao-bin Ma, Meng Wang, Shuai Lin, Mengjie Liu, Cong Dai, Zhijun Dai   +9 more
semanticscholar   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source