Results 81 to 90 of about 158,672 (304)

Tolerance of Probiotic Bacterial Candidate From Kakap Putih on Ph and Bile Salt [PDF]

, 2016
The use of probiotic is one of alternatives to solve disease problem in aquaculture. This research aimed to examine tolerance of three lactic acid bacteria (KP1, KP2, and KP3) isolated from kakap putih (Lates calcarifer) toward pH and bile salt at ...
Harjuni, F. (Fiki), Mulyadi, A. (Aras), Nursyirwani, N. (Nursyirwani)   +2 more
core  

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

The bile salt export pump [PDF]

, 2018
Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.
Meier, Peter, Meier, Yvonne, Stieger, Bruno   +2 more
core  

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Mechanistic insights into the inhibition of NTCP by myrcludex B

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Joanne M. Donkers, Monique D. Appelman, Stan F.J. van de Graaf   +2 more
doaj   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Mathematical model of biliary lipid secretion: a quantitative analysis of physiological and biochemical data from man and other species.

Journal of Lipid Research, 1984
We propose a simple mathematical model to account for the coupling of secretion rates of bile salts, lecithin, and cholesterol into bile. The model assumes that: 1) molecules of ''biliary'' lecithin and cholesterol enter a functional compartment located ...
N A Mazer, M C Carey
doaj   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities.

Journal of Lipid Research, 1982
To examine quantitatively the hydrophobic-hydrophilic properties of bile salts, we determined the reverse-phase high performance liquid chromatographic (HPLC) mobilities of monomeric bile salt solutions and the equilibrium cholesterol-solubilizing ...
M J Armstrong, M C Carey
doaj   +1 more source

A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress [PDF]

, 2014
Resistance to high concentrations of bile salts in the human intestinal tract is vital for the survival of enteric bacteria such as Escherichia coli.
Baba, Beja, Bron, Budavari, Darkoh, Datsenko, De Paepe, Doerner, Edgar, Fluman, Fralick, Gunn, Hernandez, Heuman, Hofmann, Holdsworth, Holdsworth, Holdsworth, Hylemon, Kalantzi, Kamp, Lee, Lewinson, Ley, Li, Ma, Maldonado-Valderrama, Mallonee, McDougall, Merritt, Neyfakh, Nishino, Padan, Padan, Pfaffl, Piddock, Provencher, Qin, Ridlon, Rune, Soo, Soothill, Tal, Thanassi, Whitehead, Whitmore, Yin, Yokota   +47 more
core   +1 more source