Results 1 to 10 of about 7,014 (156)

Effect of Bile Salt Hydrolase Inhibitors on a Bile Salt Hydrolase from Lactobacillus acidophilus [PDF]

Pathogens, 2014
Bile salt hydrolase (BSH), a widely distributed function of the gut microbiota, has a profound impact on host lipid metabolism and energy harvest. Recent studies suggest that BSH inhibitors are promising alternatives to antibiotic growth promoters (AGP ...
Jun Lin, Rekek Negga, Ximin Zeng, Katie Smith   +3 more
doaj   +5 more sources

Identification of Bile Salt Hydrolase and Bile Salt Resistance in a Probiotic Bacterium Lactobacillus gasseri JCM1131^T [PDF]

Microorganisms, 2021
Lactobacillus gasseri is one of the most likely probiotic candidates among many Lactobacillus species. Although bile salt resistance has been defined as an important criterion for selection of probiotic candidates since it allows probiotic bacteria to ...
Hiroyuki Kusada, Kana Morinaga, Hideyuki Tamaki   +2 more
doaj   +5 more sources

Bile salt hydrolase activity as a rational target for MASLD therapy [PDF]

Gut Microbes
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease in the United States, yet therapeutic options remain limited.
Elizabeth V. Jones, Yongtao Wang, Wenchao Wei, James C. Reed, Snehal N. Chaudhari, Darrick K. Li, Jerome Boursier, Sonja Lang, Münevver Demir, Anna Mae Diehl, Andrew S. Allegretti, Bernd Schnabl, Raymond T. Chung, A. Sloan Devlin   +13 more
doaj   +5 more sources

Electrostatic Interactions Dictate Bile Salt Hydrolase Substrate Preference. [PDF]

Biochemistry, 2023
Abstract The human intestines are colonized by trillions of microbes, comprising the gut microbiota, which produce diverse small molecule metabolites and modify host metabolites, such as bile acids, that regulate host physiology. Biosynthesized in the liver, bile acids are conjugated with glycine or taurine and secreted into the ...
Malarney KP, Chang PV.
europepmc   +4 more sources

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer [PDF]

Nature Communications, 2023
Non-enterotoxigenic Bacteroides fragilis (NTBF) is abundant in colorectal cancer (CRC) patients and in a high-fat diet (HFD)-induced CRC model. Here the authors show that bile salt hydrolase-expressing NTBF is enriched in CRC patients with overweight and 
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez   +16 more
doaj   +2 more sources

Identifying a Novel Bile Salt Hydrolase from the Keystone Gut Bacterium Christensenella minuta [PDF]

Microorganisms, 2021
Christensenella minuta are human gut dwelling bacteria that have been proposed as key members of the gut microbiome, regulating energy balance and adiposity of their host. We formerly identified that a novel strain of C.
Guillaume Déjean, Héloïse Tudela, Lisa Bruno, Déborah Kissi, Georges Rawadi, Sandrine P. Claus   +5 more
doaj   +2 more sources

Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile acids [PDF]

Nature Communications
Through biochemical transformation of host-derived bile acids, gut bacteria mediate host-microbe crosstalk and function at the interface of nutrition and host metabolic regulation.
Lauren N. Lucas, Mallikarjun Jillella, Lea E. Cattaneo, Bhavana Gangwar, Qijun Zhang, A. P. Clay, Robert L. Kerby, David M. Stevenson, Helen E. Blackwell, Federico E. Rey, Daniel Amador-Noguez   +10 more
doaj   +2 more sources

Bile salt hydrolase catalyses formation of amine-conjugated bile acids. [PDF]

Nature
Abstract Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes 1–6 ; however, the bacterial gene(s) responsible for their production remain unknown.
Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD.   +30 more
europepmc   +3 more sources

Bile Salt Hydrolase-Competent Probiotics in the Management of IBD: Unlocking the "Bile Acid Code". [PDF]

Nutrients, 2022
Bile acid (BA) species and the gut microbiota (GM) contribute to intestinal mucosa homeostasis. BAs shape the GM and, conversely, intestinal bacteria with bile salt hydrolase (BSH) activity modulate the BA pool composition. The mutual interaction between BAs and intestinal microorganisms also influences mucosal barrier integrity, which is important for
Gadaleta RM, Cariello M, Crudele L, Moschetta A.   +3 more
europepmc   +4 more sources

Taxonomic identification of bile salt hydrolase‐encoding lactobacilli: Modulation of the enterohepatic bile acid profile [PDF]

iMeta, 2023
Bile salt hydrolases (BSHs) are enzymes that are essential for the enterohepatic metabolism of bile acids (BAs). BSHs catalyze the production of unconjugated BAs and regulate the homeostasis of BA pool.
Ziwei Song, Shuo Feng, Xingchen Zhou, Zhengxing Song, Jing Li, Ping Li   +5 more
doaj   +2 more sources