Results 121 to 130 of about 109,357 (257)

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

open access: yesClinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen   +8 more
wiley   +1 more source

Regulation of haem oxygenase-1 nitrosative stress in cardiac cells. [PDF]

open access: yes, 2005
The reactive nitrogen species (RNS) nitric oxide (NO), nitroxyl anion (NO") and nitrosonium cation (NO+), modulate a myriad of biological processes. The microsomal haem oxygenases (HO-1, HO-2 and HO-3) oxidatively catabolise haem to bilirubin, carbon ...
Naughton, P.
core  

Drug-Induced Encephalopathy

open access: yes, 2022
Drug-induced encephalopathy is a condition that is frequently caused by poor cerebral metabolism rather than structural brain abnormalities. On the other hand, several drug-induced encephalopathies may develop structural abnormalities and have common ...
Zehni, Rouzbeh
core  

Five‐Year CT‐Based Skeletal Muscle Decline Curves in Cirrhosis According to Liver Functional Reserve and Routinely Available Clinical Factors

open access: yesJGH Open, Volume 10, Issue 10, October 2026.
ABSTRACT Background Sarcopenia is common in cirrhosis and is associated with poor outcomes. We aimed to identify factors associated with longitudinal skeletal muscle loss and to explore estimation of future L3 skeletal muscle index (L3‐SMI) using routinely available clinical variables. Methods This retrospective longitudinal study included 175 patients
Suguru Miida   +14 more
wiley   +1 more source

Amplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy. [PDF]

open access: yesTransl Pediatr, 2021
Chang H   +8 more
europepmc   +1 more source

Mirror covered tunnel phototherapy increases the efficacy of phototherapy for neonatal jaundice [PDF]

open access: yes
Objective: Neonatal jaundice (NJ) is one of the most common cause of neonatal hospital admission. Phototherapy is the main therapy for hyperbilirubinemia of neonatal jaundice. The efficacy of phototherapy depends on the dose and wavelength of light used
امینی ثانی, نیره   +6 more
core  

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus   +8 more
wiley   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

open access: yesAngewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang   +12 more
wiley   +2 more sources

Review article: Immunosuppression in Decompensated Autoimmune Hepatitis Cirrhosis ‐ To Suppress or Not to Suppress?

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 897-918, October 2026.
Individualized assessment identifies patients with decompensated autoimmune hepatitis cirrhosis who are likely to benefit from a time‐limited trial of immunosuppression versus those requiring immediate liver transplant evaluation. Early objective response monitoring (bilirubin, MELD‐Na and AST/ALT) guides continuation of immunosuppression, promotes ...
Pedro Robson Costa Passos   +2 more
wiley   +1 more source

Developmental outcome of neonates underwent exchange transfusion due to hyperbilirubinemia: A single-center experience

open access: yesJournal of Education and Health Promotion
BACKGROUND: Exchange transfusion due to hyperbilirubinemia is performed in neonates with signs of encephalopathy or if the level of bilirubin is more than the exchange threshold and not responding to intensive phototherapy.
Khadije Sadat Najib   +3 more
doaj   +1 more source

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