Results 161 to 170 of about 1,516 (196)
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Mixed antagonistic effects of bilobalide at ρ1 GABAC receptor
Neuroscience, 2006Bilobalide was found to be a moderately potent antagonist with a weak use-dependent effect at recombinant human rho(1) GABA(C) receptors expressed in Xenopus oocytes using two-electrode voltage clamp methodology. Antagonism of bilobalide at homomeric rho(1) GABA(C) receptors appeared to be mixed.
S H, Huang +5 more
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Determination of ginkgolides and bilobalide in Ginkgo biloba leaves and phytopharmaceuticals
Journal of Chromatography A, 1991Abstract A method has been developed for the determination of the pharmacologically active terpenoids ginkgolide A, B and C and bilobalide in Ginkgo biloba leaves and phytopharmaceutical preparations containing ginkgo extracts. The leaves (400–800 mg) ar selectively extracted with methanol—water (10:90) and the resulting extract is purified by ...
van Beek, T.A. +4 more
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[Mechanism of bilobalide promoting neuroprotection of macrophages].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023This study aims to explore the neuroprotective effect of bilobalide(BB) and the mechanisms such as inhibiting inflammatory response in macrophage/microglia, promoting neurotrophic factor secretion, and interfering with the activation and differentiation of peripheral CD4~+ T cells. BB of different concentration(12.5, 25, 50, 100 μg·mL~(-1)) was used to
Yang-Yang, Chen +7 more
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International Journal of Neuroscience, 2022
Background: The etiology of Parkinson's disease (PD), a chronic and progressive neurodegenerative disease, is multifactorial but not fully unknown. Until now, no drug has been proven to have neuroprotective or neuroregenerative effects in patients with PD.
Li-Juan Song +12 more
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Background: The etiology of Parkinson's disease (PD), a chronic and progressive neurodegenerative disease, is multifactorial but not fully unknown. Until now, no drug has been proven to have neuroprotective or neuroregenerative effects in patients with PD.
Li-Juan Song +12 more
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Synthetic studies on the ginkgolides: total synthesis of (.+-.)-bilobalide
Journal of the American Chemical Society, 1993Two syntheses of the C15 ginkgolide, bilobalide, are presented. One approach results in a formal synthesis by intersecting an intermediate in the Corey synthesis, while a second approach results in a completed total synthesis which is considerably shorter than the first.
Michael T. Crimmins +2 more
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Fundamental & Clinical Pharmacology, 2000
Abstract— Ischaemia is a common feature of most vascular diseases. There is evidence from experimental and clinical studies that Ginkgo biloba extract protects tissues from ischaemia/reperfusion damages. Bilobalide seems to be responsible, at least in part, for this activity.
Janssens, Dominique +3 more
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Abstract— Ischaemia is a common feature of most vascular diseases. There is evidence from experimental and clinical studies that Ginkgo biloba extract protects tissues from ischaemia/reperfusion damages. Bilobalide seems to be responsible, at least in part, for this activity.
Janssens, Dominique +3 more
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Enantioselective total synthesis of bilobalide, A C15 ginkgolide
Tetrahedron Letters, 1988Abstract An enantioselective total synthesis of bilobalide 1 has been effected from diester 5 using stereospecific conversion to 7 via intermediate 6 .
E.J. Corey, Wei-guo Su
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The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice
Metabolic Brain Disease, 2020Inflammatory demyelination in the central nervous system (CNS) is a hallmark of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Besides MS disease-modifying therapy, targeting myelin sheath protection/regeneration is currently a hot spot in the treatment of MS.
Qiang, Miao +12 more
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Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide
Brain Research, 2008Bilobalide, a constituent of Ginkgo biloba, has neuroprotective properties. Its mechanism of action is unknown but it was recently found to interact with neuronal transmission mediated by glutamate, gamma-aminobutyric acid (GABA) and glycine. The goal of this study was to test the interaction of bilobalide with glycine in assays of neuroprotection.
Cornelia, Kiewert +5 more
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Supercritical fluid chromatography of ginkgolides A, B, C and J and bilobalide
Journal of Chromatography A, 1996Abstract Supercritical fluid chromatography (SFC) can be used to separate the five different ginkgo terpenetrilactones occurring in Ginkgo biloba leaf. The separation is carried out at 280 atm on a packed deactivated aminophrophyl silica HPLC column with CO2 modified with 12% methanol.
J. Thompson +3 more
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