Results 1 to 10 of about 253,228 (248)
Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]
PeerJ, 2023 Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
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Non-microRNA binding competitively inhibits LIN28 regulation [PDF]
Cell Reports, 2021 RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best known for its direct regulation of let-7 miRNA biogenesis, is also indirectly regulated by its widespread binding of ...
Frederick E. Tan +3 more
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Heliyon, 2023 P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo +4 more
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Competitive aptamer switch for modulating ligand binding affinity
Advanced Agrochem, 2023 Aptamers are short, single-stranded DNA or RNA molecules that selectively bind to a target molecule. Aptamer-complement duplex (ACD) is often used to design molecular switches capable of producing a detectable signal or triggering a structural change ...
Derek Puyat +3 more
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Is styrene competitive for dopamine receptor binding?
Biomolecular Concepts, 2022 The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations.
De Santis Emiliano +4 more
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Competition between LIM-binding domains [PDF]
Biochemical Society Transactions, 2008 LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline +8 more
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Computational fragment-based binding site identification by ligand competitive saturation. [PDF]
PLoS Computational Biology, 2009 Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
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Integrating binding and expression data to predict transcription factors combined function
BMC Genomics, 2020 Background Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins. These proteins form complexes
Mahmoud Ahmed +2 more
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Diffusion-induced competitive two-site binding [PDF]
The Journal of Chemical Physics, 2019 The influence of diffusion on the kinetics of ligand binding to a macromolecule with two sites is considered for a simple model where, in the reaction-controlled limit, there is no cooperativity and hence the sites are independent. By applying our recently developed formalism to describe a network of coupled diffusion-influenced reactions, we show that
Irina V. Gopich, Attila Szabo
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Competitive dCas9 binding as a mechanism for transcriptional control
Molecular Systems Biology, 2021 Catalytically dead Cas9 (dCas9) is a programmable transcription factor that can be targeted to promoters through the design of small guide RNAs (sgRNAs), where it can function as an activator or repressor.
Daniel A Anderson, Christopher A Voigt
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