Results 21 to 30 of about 253,228 (248)
Frontiers in Pharmacology, 2022 Our group has developed and experimentally validated a strategy to increase antibody penetration in solid tumors through transient inhibition of antibody-antigen binding. In prior work, we demonstrated that 1HE, an anti-trastuzumab single domain antibody
Brandon M. Bordeau +4 more
doaj +1 more source
6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. [PDF]
PLoS ONE, 2012 BACKGROUND: ATP-dependent D-alanine:D-alanine ligase (Ddl) is a part of biochemical machinery involved in peptidoglycan biosynthesis, as it catalyzes the formation of the terminal D-ala-D-ala dipeptide of the peptidoglycan precursor UDPMurNAc ...
Veronika Škedelj +13 more
doaj +1 more source
Food Chemistry: X, 2023 The combined application of multiple natural polyphenols in functional foods may provide better health benefits. The binding of polyphenols with different structures to proteins will affect their respective functions.
Xin Qi +9 more
doaj +1 more source
Characterisation of the Binding Properties of
Journal of Experimental & Clinical Cancer Research, 2010 Background Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18 toxin for CEM-SS (T lymphoblastic ...
Nadarajah Vishna D +3 more
doaj +1 more source
BMC Chemistry, 2023 The direct binding of antiviral agents; Daclatasvir and valacyclovir and green synthesized nanoparticles to salmon sperm DNA have been assessed in a comparative study.
Ahmed Faried Abdel Hakiem +4 more
doaj +1 more source
Competitive ligand binding kinetics to linear polymers
Physical Review E, 2023 Different types of ligands compete in binding to polymers with different consequences for the physical and chemical properties of the resulting complex. Here, we derive a general kinetic model for the competitive binding kinetics of different types of ligands to a linear polymer, using the McGhee and von Hippel detailed binding site counting procedure.
Juan P. G. Villaluenga +2 more
openaire +4 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Identification and Functional Analysis of SlitOBP11 From Spodoptera litura
Frontiers in Physiology, 2021 Odorant binding proteins (OBPs) play a key role in the olfactory recognition of insects, whose functions have been extensively studied in adult insects but rarely in larvae.
Jiaojiao Luo +16 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A competitive binding between O2 and epoxy with carbon nanotubes
AIP Advances, 2017 Simulation and observation reveal a competitive binding between O2 and epoxy with carbon nanotubes. Air absorption limits tube-polymer interacting coverage and weakens the van der Waals forces.
Hsin-Jung Tsai +3 more
doaj +1 more source