Results 221 to 230 of about 1,463,984 (318)

Secondary Binding Site of CYP17A1 in Enhanced Sampling Simulations. [PDF]

J Chem Inf Model
Wróbel TM, Bartuzi D, Kaczor AA.
europepmc   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics. [PDF]

J Med Chem
Kuhne S, Bosma R, Kooistra AJ, Riemens R, Stroet MCM, Vischer HF, de Graaf C, Wijtmans M, Leurs R, de Esch IJP.   +9 more
europepmc   +1 more source

Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis.

, 1978
Örjan Wränge, Jan-Ακε Gustafsson
openalex   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I. [PDF]

Chemistry
Horiuchi N, Omer R, Sugino F, Ogino N, Inoue Y, Aslamuzzaman K, Suzuki T, Sebti SM, Ohkanda J.   +8 more
europepmc   +1 more source

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

, 1977
Ira D. Goldfine, George J. Smith, K. Y. Wong, A. L. Jones   +3 more
openalex   +1 more source

A Perspective on Powder Metallurgy and Additive Manufacturing of High‐Nitrogen Alloyed Stainless Steels

Advanced Engineering Materials, EarlyView.
This perspective article explores an innovative powder metallurgical approach to producing high‐nitrogen steels by utilizing a mixture of stainless steel and Si3N4. This mixture undergoes hot isostatic pressing followed by direct quenching. The article also examines adapting this method to laser powder bed fusion (PBF‐LB/M) to overcome nitrogen ...
Louis Becker, Felix Radtke, Jonathan Lentz, Simone Herzog, Christoph Broeckmann, Sebastian Weber   +5 more
wiley   +1 more source

Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation. [PDF]

Proc Natl Acad Sci U S A
Shen CH, Komi Y, Nakagawa Y, Kamatari YO, Nomura T, Kimura H, Shida T, Burke J, Tamai S, Ishida Y, Tanaka M.   +10 more
europepmc   +1 more source

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation.

, 1979
William A. Catterall
openalex   +1 more source