PocketMatch: A new algorithm to compare binding sites in protein structures [PDF]
, 2008 Background: Recognizing similarities and deriving relationships among protein molecules is a fundamental requirement in present-day biology.
A Argyrou +25 more
core +6 more sources
Adaptive evolution of transcription factor binding sites [PDF]
, 2004 The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in the ...
Berg, Johannes +2 more
core +4 more sources
Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function
Biomolecules, 2022 GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4).
Kate M. Crowther +2 more
doaj +1 more source
Targets for the MalI repressor at the divergent Escherichia coliK-12malX-malI promoters [PDF]
, 2010 Random mutagenesis has been used to identify the target DNA sites for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. The malX promoter is repressed by MalI binding to a DNA site located from position -24 to position -9 ...
Barnard +22 more
core +1 more source
Influence of N–1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor [PDF]
Journal of the Serbian Chemical Society, 2006 Serotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology.
MARIO V. ZLATOVIC +4 more
doaj +3 more sources
Frontiers in Immunology, 2019 Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant ...
Felicity Kendrick +4 more
doaj +1 more source
Structural Analysis and Stochastic Modelling Suggest a Mechanism for Calmodulin Trapping by CaMKII [PDF]
, 2012 Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Le Novère, Nicolas +2 more
core +4 more sources
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. [PDF]
, 2019 Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication.
Du Bois, J +4 more
core +2 more sources
Mild Hypogammaglobulinemia Can Be a Serious Condition
Frontiers in Immunology, 2018 Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD).
Lisanne M. A. Janssen +10 more
doaj +1 more source
PocketGraph : graph representation of binding site volumes [PDF]
, 2009 The representation of small molecules as molecular graphs is a common technique in various fields of cheminformatics. This approach employs abstract descriptions of topology and properties for rapid analyses and comparison.
Kriegl, Jan M. +2 more
core +1 more source