Results 21 to 30 of about 1,488,867 (343)
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression [PDF]
Phys. Rev. E 95, 042412 (2017), 2016 Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters.
arxiv +1 more source
Deep learning for MYC binding site recognition
Frontiers in Bioinformatics, 2022 Motivation: The definition of the genome distribution of the Myc transcription factor is extremely important since it may help predict its transcriptional activity particularly in the context of cancer.
R. Fioresi, P. Demurtas, G. Perini
doaj +1 more source
Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function
Biomolecules, 2022 GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4).
Kate M. Crowther +2 more
doaj +1 more source
The metal binding site of zoocin A [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2008 Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Gary L. Sloan +3 more
openaire +3 more sources
The evolution of complex gene regulation by low specificity binding sites [PDF]
Proc. R. Soc. B 7 October 2013 vol. 280 no. 1768 20131313, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost.
arxiv +1 more source
Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023 Introduction: Clonal plasma cells secrete immunoglobulins, each with the exact same amino acid sequence, that are referred to as monoclonal immunoglobulins.
David R. Barnidge +3 more
doaj
How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?
Frontiers in Chemistry, 2018 Knowledge of the bioactive conformations of small molecules or the ability to predict them with theoretical methods is of key importance to the design of bioactive compounds such as drugs, agrochemicals, and cosmetics.
Nils-Ole Friedrich +3 more
doaj +1 more source
Spatial Layouts of Low‐Entropy Hydration Shells Guide Protein Binding
Global Challenges, 2023 Protein–protein binding enables orderly biological self‐organization and is therefore considered a miracle of nature. Protein‒protein binding is driven by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions.
Lin Yang +9 more
doaj +1 more source
Frontiers in Pharmacology, 2022 The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs.
Alejandro Valdés-Jiménez +11 more
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Ethanol binding sites on proteins
Journal of Molecular Graphics and Modelling, 2017 This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V. +2 more
openaire +4 more sources