Results 21 to 30 of about 8,774,932 (333)
miR-496 inhibits proliferation via LYN and AKT pathway in gastric cancer
Open Medicine, 2021 MicroRNAs (miRNAs) operate as tumor suppressor or carcinogen to regulate cell proliferation, metastasis, invasion, differentiation, apoptosis, and metabolic process.
Su Rui, Zhao Enhong, Zhang Jun
doaj +1 more source
Computing the protein binding sites [PDF]
BMC Bioinformatics, 2011 Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions.
Guo, Fei, Wang, Lusheng
openaire +2 more sources
Frontiers in Immunology, 2019 Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant ...
Felicity Kendrick +4 more
doaj +1 more source
P53 Binding Sites in Transposons [PDF]
Frontiers in Genetics, 2012 Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Zemojtel, T., Vingron, M.
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Adaptive evolution of transcription factor binding sites [PDF]
, 2004 The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in the ...
Berg, Johannes +2 more
core +4 more sources
PrankWeb: a web server for ligand binding site prediction and visualization
Nucleic Acids Res., 2019 PrankWeb is an online resource providing an interface to P2Rank, a state-of-the-art method for ligand binding site prediction. P2Rank is a template-free machine learning method based on the prediction of local chemical neighborhood ligandability centered
Lukás Jendele +4 more
semanticscholar +1 more source
Structural Analysis and Stochastic Modelling Suggest a Mechanism for Calmodulin Trapping by CaMKII [PDF]
, 2012 Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Le Novère, Nicolas +2 more
core +4 more sources
Mild Hypogammaglobulinemia Can Be a Serious Condition
Frontiers in Immunology, 2018 Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD).
Lisanne M. A. Janssen +10 more
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Deep learning for MYC binding site recognition
Frontiers in Bioinformatics, 2022 Motivation: The definition of the genome distribution of the Myc transcription factor is extremely important since it may help predict its transcriptional activity particularly in the context of cancer.
R. Fioresi, P. Demurtas, G. Perini
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Ligand docking and binding site analysis with PyMOL and Autodock/Vina
J. Comput. Aided Mol. Des., 2010 Docking of small molecule compounds into the binding site of a receptor and estimating the binding affinity of the complex is an important part of the structure-based drug design process.
Daniel Seeliger, B. L. de Groot
semanticscholar +1 more source