Results 21 to 30 of about 1,513,732 (317)

Mild Hypogammaglobulinemia Can Be a Serious Condition

Frontiers in Immunology, 2018
Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD).
Lisanne M. A. Janssen, Paul Bassett, Thomas Macken, Jolanda van Esch, Hans Pruijt, Arnoud Knoops, Markus Sköld, Antony Parker, Jolanda de Vries, Esther de Vries, Esther de Vries   +10 more
doaj   +1 more source

The response to Typhi Vi vaccination is compromised in individuals with primary immunodeficiency

Heliyon, 2017
Measurement of an individuals ability to respond to polysaccharide antigens is a crucial test to determine adaptive immunity. Currently the response to Pneumovax® is utilized but with the success of Prevnar®, measurement of the response to Pneumovax may ...
Jeevani Kumarage, Suranjith L. Seneviratne, Vijitha Senaratne, Amitha Fernando, Kirthi Gunasekera, Bandu Gunasena, Padmalal Gurugama, Sudath Peiris, Antony R. Parker, Stephen Harding, Nilhan Rajiva de Silva   +10 more
doaj   +1 more source

Deep learning for MYC binding site recognition

Frontiers in Bioinformatics, 2022
Motivation: The definition of the genome distribution of the Myc transcription factor is extremely important since it may help predict its transcriptional activity particularly in the context of cancer.
R. Fioresi, P. Demurtas, G. Perini
doaj   +1 more source

The metal binding site of zoocin A [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2008
Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Gary L. Sloan, Robin S. Simmonds, Russell Timkovich, Yinghua Chen   +3 more
openaire   +3 more sources

How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?

Frontiers in Chemistry, 2018
Knowledge of the bioactive conformations of small molecules or the ability to predict them with theoretical methods is of key importance to the design of bioactive compounds such as drugs, agrochemicals, and cosmetics.
Nils-Ole Friedrich, Méliné Simsir, Méliné Simsir, Johannes Kirchmair   +3 more
doaj   +1 more source

Spatial Layouts of Low‐Entropy Hydration Shells Guide Protein Binding

Global Challenges, 2023
Protein–protein binding enables orderly biological self‐organization and is therefore considered a miracle of nature. Protein‒protein binding is driven by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions.
Lin Yang, Shuai Guo, Chenchen Liao, Chengyu Hou, Shenda Jiang, Jiacheng Li, Xiaoliang Ma, Liping Shi, Lin Ye, Xiaodong He   +9 more
doaj   +1 more source

ATAC-Seq Data for Genome-Wide Profiling of Transcription Factor Binding Sites in the Rice False Smut Fungus Ustilaginoidea virens

Molecular Plant-Microbe Interactions, 2021
Identification of transcription factor binding sites is one of the most important steps in understanding the function of transcription factors and regulatory networks in organisms. The assay for transposase accessible chromatin sequencing (ATAC-seq) is a
Xiaoyang Chen, Hao Liu, Xiaolin Chen, Junbin Huang, Tom Hsiang, Lu Zheng   +5 more
doaj   +1 more source

Ethanol binding sites on proteins

Journal of Molecular Graphics and Modelling, 2017
This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V., Khrustaleva, T. A., Lelevich, S. V.   +2 more
openaire   +4 more sources

Endogenous monoclonal immunoglobulins analyzed using the EXENT® solution and LC-MS

Journal of Mass Spectrometry and Advances in the Clinical Lab
Introduction: The EXENT® Solution, a fully automated system, is a recent advancement for identifying and quantifying monoclonal immunoglobulins in serum. It combines immunoprecipitation with MALDI-TOF mass spectrometry.
David Barnidge, Derek Troske, Simon North, Gregg Wallis, Mark Perkins, Stephen Harding   +5 more
doaj   +1 more source

Characterization of α-actin isoforms in white and red skeletal muscle types of Leporinus macrocephalus (Characiformes, Anostomidae)

Anais da Academia Brasileira de Ciências, 2015
RESUMO Dois genes de α-actina do peixe Leporinus macrocephalus, referindo-se aos tecidos musculares branco e vermelho, foram isolados. Isoformas de actinas, que principalmente diferiram por uma substituição Ser/Ala155, podem ter uma significância ...
FERNANDA A. ALVES-COSTA, MAELI D.P. SILVA, ADRIANE P. WASKO   +2 more
doaj   +1 more source